Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases
Autophagy is a highly conserved catabolic process involving autolysosomal degradation of cellular components, including protein aggregates, damaged organelles (such as mitochondria, endoplasmic reticulum, and others), as well as various pathogens. Thus, the autophagy pathway represents a major adapt...
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| Format: | Article |
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MDPI AG
2019-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/2/123 |
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| author | Kui Wang Yi Chen Pengju Zhang Ping Lin Na Xie Min Wu |
| author_facet | Kui Wang Yi Chen Pengju Zhang Ping Lin Na Xie Min Wu |
| author_sort | Kui Wang |
| collection | DOAJ |
| description | Autophagy is a highly conserved catabolic process involving autolysosomal degradation of cellular components, including protein aggregates, damaged organelles (such as mitochondria, endoplasmic reticulum, and others), as well as various pathogens. Thus, the autophagy pathway represents a major adaptive response for the maintenance of cellular and tissue homeostasis in response to numerous cellular stressors. A growing body of evidence suggests that autophagy is closely associated with diverse human diseases. Specifically, acute lung injury (ALI) and inflammatory responses caused by bacterial infection or xenobiotic inhalation (e.g., chlorine and cigarette smoke) have been reported to involve a spectrum of alterations in autophagy phenotypes. The role of autophagy in pulmonary infection and inflammatory diseases could be protective or harmful dependent on the conditions. In this review, we describe recent advances regarding the protective features of autophagy in pulmonary diseases, with a focus on ALI, idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), tuberculosis, pulmonary arterial hypertension (PAH) and cystic fibrosis. |
| first_indexed | 2024-03-12T10:58:22Z |
| format | Article |
| id | doaj.art-3dcc1e196d024fee997dfd4714bcc2c0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T10:58:22Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3dcc1e196d024fee997dfd4714bcc2c02023-09-02T06:02:01ZengMDPI AGCells2073-44092019-02-018212310.3390/cells8020123cells8020123Protective Features of Autophagy in Pulmonary Infection and Inflammatory DiseasesKui Wang0Yi Chen1Pengju Zhang2Ping Lin3Na Xie4Min Wu5West China School of Basic Medical Sciences & Forensic Medicine, and State Key Laboratory of Biotherapy, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, ChinaDepartment of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, ChinaWest China School of Basic Medical Sciences & Forensic Medicine, and State Key Laboratory of Biotherapy, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, ChinaDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58203, USAWest China School of Basic Medical Sciences & Forensic Medicine, and State Key Laboratory of Biotherapy, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, ChinaDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58203, USAAutophagy is a highly conserved catabolic process involving autolysosomal degradation of cellular components, including protein aggregates, damaged organelles (such as mitochondria, endoplasmic reticulum, and others), as well as various pathogens. Thus, the autophagy pathway represents a major adaptive response for the maintenance of cellular and tissue homeostasis in response to numerous cellular stressors. A growing body of evidence suggests that autophagy is closely associated with diverse human diseases. Specifically, acute lung injury (ALI) and inflammatory responses caused by bacterial infection or xenobiotic inhalation (e.g., chlorine and cigarette smoke) have been reported to involve a spectrum of alterations in autophagy phenotypes. The role of autophagy in pulmonary infection and inflammatory diseases could be protective or harmful dependent on the conditions. In this review, we describe recent advances regarding the protective features of autophagy in pulmonary diseases, with a focus on ALI, idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), tuberculosis, pulmonary arterial hypertension (PAH) and cystic fibrosis.https://www.mdpi.com/2073-4409/8/2/123Autophagyinflammationacute lung injuryidiopathic pulmonary fibrosisCOPDtuberculosisPAHcystic fibrosis |
| spellingShingle | Kui Wang Yi Chen Pengju Zhang Ping Lin Na Xie Min Wu Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases Cells Autophagy inflammation acute lung injury idiopathic pulmonary fibrosis COPD tuberculosis PAH cystic fibrosis |
| title | Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases |
| title_full | Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases |
| title_fullStr | Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases |
| title_full_unstemmed | Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases |
| title_short | Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases |
| title_sort | protective features of autophagy in pulmonary infection and inflammatory diseases |
| topic | Autophagy inflammation acute lung injury idiopathic pulmonary fibrosis COPD tuberculosis PAH cystic fibrosis |
| url | https://www.mdpi.com/2073-4409/8/2/123 |
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