HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer

HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer

The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure. Hyaluronan synthase 2 (HAS2) is the most critical synthase in producing hyaluronan and is well known f...

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Bibliographic Details
Main Authors: Xiaodan Sun, Fen Tang, Qian Guo, Yiwen Liu, Yiqing He, Yan Du, Feng Gao, Guoliang Zhang, Cuixia Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
endocrine resistance
HAS2
Ezrin
ERα
antiestrogens
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1031487/full

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