Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4
Abstract Introduction: This study investigated the correlation between the levels of long noncoding ribonucleic acids (lncRNAs) AF131217.1 and coronary slow flow (CSF). Methods: A total of 22 patients in the high-sensitivity C-reactive protein (hsCRP) group diagnosed with CSF from January 2018 to...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
2021-12-01
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382021005008219&tlng=en |
| _version_ | 1818252904029487104 |
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| author | Haibing Jiang Zhengrong Ge Lijing Zhang Yi Yang Xueqin Zhai Zhanxi Chen Qing Wei |
| author_facet | Haibing Jiang Zhengrong Ge Lijing Zhang Yi Yang Xueqin Zhai Zhanxi Chen Qing Wei |
| author_sort | Haibing Jiang |
| collection | DOAJ |
| description | Abstract Introduction: This study investigated the correlation between the levels of long noncoding ribonucleic acids (lncRNAs) AF131217.1 and coronary slow flow (CSF). Methods: A total of 22 patients in the high-sensitivity C-reactive protein (hsCRP) group diagnosed with CSF from January 2018 to December 2018 were enrolled in this study. Coronary flow velocity was determined using the thrombolysis in myocardial infarction frame count (TFC) method. Results: LncRNA AF131217.1 expression in the CSF model was activated. Mean TFC was positively correlated with lncRNA AF131217.1 levels and hsCRP levels. LncRNA AF131217.1 induced inflammation factor levels in the in vitro model. Micro ribonucleic acid (miR)-128-3p is a target spot of lncRNA AF131217.1 on the inflammation in vitro model via Kruppel-like factor (KLF) 4. MiR-128-3p reduced inflammation factor levels (tumor necrosis factor alpha, interleukin [IL]-6, IL-1β, and IL-18). Conclusion: Thus, lncRNA AF131217.1 promoted inflammation in the regulated CSF via KLF4 by miR-128-3p. |
| first_indexed | 2024-12-12T16:31:35Z |
| format | Article |
| id | doaj.art-3dcd0e2585b14f7b9436043a56d59763 |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-12-12T16:31:35Z |
| publishDate | 2021-12-01 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-3dcd0e2585b14f7b9436043a56d597632022-12-22T00:18:46ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-97412021-12-0110.21470/1678-9741-2020-0573Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4Haibing Jianghttps://orcid.org/0000-0002-9716-1921Zhengrong GeLijing ZhangYi YangXueqin ZhaiZhanxi ChenQing WeiAbstract Introduction: This study investigated the correlation between the levels of long noncoding ribonucleic acids (lncRNAs) AF131217.1 and coronary slow flow (CSF). Methods: A total of 22 patients in the high-sensitivity C-reactive protein (hsCRP) group diagnosed with CSF from January 2018 to December 2018 were enrolled in this study. Coronary flow velocity was determined using the thrombolysis in myocardial infarction frame count (TFC) method. Results: LncRNA AF131217.1 expression in the CSF model was activated. Mean TFC was positively correlated with lncRNA AF131217.1 levels and hsCRP levels. LncRNA AF131217.1 induced inflammation factor levels in the in vitro model. Micro ribonucleic acid (miR)-128-3p is a target spot of lncRNA AF131217.1 on the inflammation in vitro model via Kruppel-like factor (KLF) 4. MiR-128-3p reduced inflammation factor levels (tumor necrosis factor alpha, interleukin [IL]-6, IL-1β, and IL-18). Conclusion: Thus, lncRNA AF131217.1 promoted inflammation in the regulated CSF via KLF4 by miR-128-3p.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382021005008219&tlng=enMyocardial InfarctationInflammationInterleukin-18Interleukin-6RNALong NoncodingC-Reactive ProteinMicroRNAsGKLF protein |
| spellingShingle | Haibing Jiang Zhengrong Ge Lijing Zhang Yi Yang Xueqin Zhai Zhanxi Chen Qing Wei Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 Brazilian Journal of Cardiovascular Surgery Myocardial Infarctation Inflammation Interleukin-18 Interleukin-6 RNA Long Noncoding C-Reactive Protein MicroRNAs GKLF protein |
| title | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 |
| title_full | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 |
| title_fullStr | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 |
| title_full_unstemmed | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 |
| title_short | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 |
| title_sort | long noncoding rna af131217 1 regulated coronary slow flow induced inflammation affecting coronary slow flow via klf4 |
| topic | Myocardial Infarctation Inflammation Interleukin-18 Interleukin-6 RNA Long Noncoding C-Reactive Protein MicroRNAs GKLF protein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382021005008219&tlng=en |
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