Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapy
Pneumococcal polysaccharide vaccination may be associated with adverse outcomes in HIV-infected individuals who did not receive highly active antiretroviral therapy (HAART). Our aim was to evaluate the impact of vaccination with seven-valent pneumococcal conjugate vaccine (PCV) on the short-term cli...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-08-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664612000794 |
| _version_ | 1811255650480553984 |
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| author | Ching-Lan Lu Sui-Yuan Chang Hsin-Yun Sun Wen-Chun Liu Yu-Tzu Tseng Chia-Ying Hsieh Cheng-Hsin Wu Chien-Ching Hung Shan-Chwen Chang |
| author_facet | Ching-Lan Lu Sui-Yuan Chang Hsin-Yun Sun Wen-Chun Liu Yu-Tzu Tseng Chia-Ying Hsieh Cheng-Hsin Wu Chien-Ching Hung Shan-Chwen Chang |
| author_sort | Ching-Lan Lu |
| collection | DOAJ |
| description | Pneumococcal polysaccharide vaccination may be associated with adverse outcomes in HIV-infected individuals who did not receive highly active antiretroviral therapy (HAART). Our aim was to evaluate the impact of vaccination with seven-valent pneumococcal conjugate vaccine (PCV) on the short-term clinical, virologic, and immunologic outcomes among HIV-infected adult patients in the HAART era.
Methods: A total of 429 HIV-infected adult patients were enrolled from October 2008 to March 2010: 213 received two doses of seven-valent PCV given at a 4-week interval and 216 received one dose. All patients were given 1-week diary to record any discomfort after vaccination. Data of serial CD4 and plasma HIV RNA load measurements were recorded.
Results: Of the 429 patients with a mean CD4 count of 305 cells/μL, 289 (67.4%) were receiving HAART and 175 (40.8%) had plasma HIV RNA load <40 copies/mL at vaccination. Of the 396 patients (92.3%) who returned the diary, injection site soreness (24.0%) and pain (10.4%) were the most commonly reported adverse effects. After 3–4 months of vaccination, CD4 count increased by 40 cells/μL in 278 patients (68.2%) who continued HAART, compared with a decrease of 38 cells/μL in 131 patients (31.8%) who were not on HAART (p < 0.001), while the respective change in plasma HIV RNA load was 0.8 versus 0.2 log10 copies/mL (p = 0.09). One patient died, two developed opportunistic infections, and one developed pneumococcal pneumonia following vaccination.
Conclusion: Vaccination with seven-valent PCV among HIV-infected patients is generally safe, which has no detrimental effect on CD4 count and plasma HIV RNA load in patients receiving HAART. (ClinicalTrials.gov number, NCT00885628). |
| first_indexed | 2024-04-12T17:27:59Z |
| format | Article |
| id | doaj.art-3dcd217a93244f0babf0391900503fa3 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-12T17:27:59Z |
| publishDate | 2012-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-3dcd217a93244f0babf0391900503fa32022-12-22T03:23:14ZengElsevierJournal of the Formosan Medical Association0929-66462012-08-01111844545110.1016/j.jfma.2011.06.027Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapyChing-Lan Lu0Sui-Yuan Chang1Hsin-Yun Sun2Wen-Chun Liu3Yu-Tzu Tseng4Chia-Ying Hsieh5Cheng-Hsin Wu6Chien-Ching Hung7Shan-Chwen Chang8Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, TaiwanDepartment of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanTaipei City Hospital, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanPneumococcal polysaccharide vaccination may be associated with adverse outcomes in HIV-infected individuals who did not receive highly active antiretroviral therapy (HAART). Our aim was to evaluate the impact of vaccination with seven-valent pneumococcal conjugate vaccine (PCV) on the short-term clinical, virologic, and immunologic outcomes among HIV-infected adult patients in the HAART era. Methods: A total of 429 HIV-infected adult patients were enrolled from October 2008 to March 2010: 213 received two doses of seven-valent PCV given at a 4-week interval and 216 received one dose. All patients were given 1-week diary to record any discomfort after vaccination. Data of serial CD4 and plasma HIV RNA load measurements were recorded. Results: Of the 429 patients with a mean CD4 count of 305 cells/μL, 289 (67.4%) were receiving HAART and 175 (40.8%) had plasma HIV RNA load <40 copies/mL at vaccination. Of the 396 patients (92.3%) who returned the diary, injection site soreness (24.0%) and pain (10.4%) were the most commonly reported adverse effects. After 3–4 months of vaccination, CD4 count increased by 40 cells/μL in 278 patients (68.2%) who continued HAART, compared with a decrease of 38 cells/μL in 131 patients (31.8%) who were not on HAART (p < 0.001), while the respective change in plasma HIV RNA load was 0.8 versus 0.2 log10 copies/mL (p = 0.09). One patient died, two developed opportunistic infections, and one developed pneumococcal pneumonia following vaccination. Conclusion: Vaccination with seven-valent PCV among HIV-infected patients is generally safe, which has no detrimental effect on CD4 count and plasma HIV RNA load in patients receiving HAART. (ClinicalTrials.gov number, NCT00885628).http://www.sciencedirect.com/science/article/pii/S0929664612000794antiretroviral therapyhighly active antiretroviral therapyHIV infectionHIV RNA loadpneumococcal conjugate vaccineStreptococcus pneumoniae |
| spellingShingle | Ching-Lan Lu Sui-Yuan Chang Hsin-Yun Sun Wen-Chun Liu Yu-Tzu Tseng Chia-Ying Hsieh Cheng-Hsin Wu Chien-Ching Hung Shan-Chwen Chang Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapy Journal of the Formosan Medical Association antiretroviral therapy highly active antiretroviral therapy HIV infection HIV RNA load pneumococcal conjugate vaccine Streptococcus pneumoniae |
| title | Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapy |
| title_full | Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapy |
| title_fullStr | Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapy |
| title_full_unstemmed | Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapy |
| title_short | Impact of vaccination with seven-valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among HIV-infected adult patients in the era of highly active antiretroviral therapy |
| title_sort | impact of vaccination with seven valent pneumococcal conjugate vaccine on virologic and immunologic outcomes among hiv infected adult patients in the era of highly active antiretroviral therapy |
| topic | antiretroviral therapy highly active antiretroviral therapy HIV infection HIV RNA load pneumococcal conjugate vaccine Streptococcus pneumoniae |
| url | http://www.sciencedirect.com/science/article/pii/S0929664612000794 |
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