Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar.
BACKGROUND: Tuberculosis continues to cause unacceptably high levels of disease and death worldwide. Active preventive strategies are required to improve tuberculosis control and to increase the number of cases treated in developing countries. The aim of this study was to evaluate the utility of the...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3990634?pdf=render |
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| author | Rila Ratovoson Voamalala Raharimanga Niaina Rakotosamimanana B Ravaloson Maherisosa Ratsitorahina Rindra Randremanana Herimanana Ramarokoto Soatiana Rajatonirina Voahangy Rasolofo Vincent Richard |
| author_facet | Rila Ratovoson Voamalala Raharimanga Niaina Rakotosamimanana B Ravaloson Maherisosa Ratsitorahina Rindra Randremanana Herimanana Ramarokoto Soatiana Rajatonirina Voahangy Rasolofo Vincent Richard |
| author_sort | Rila Ratovoson |
| collection | DOAJ |
| description | BACKGROUND: Tuberculosis continues to cause unacceptably high levels of disease and death worldwide. Active preventive strategies are required to improve tuberculosis control and to increase the number of cases treated in developing countries. The aim of this study was to evaluate the utility of the tuberculin skin test (TST) in first-year schoolchildren as a means of increasing the number of tuberculosis cases detected through the screening of close contacts. METHODS: All members of the households of 90 schoolchildren assigned to three groups on the basis of TST category (≤ 5 mm, [5-15)mm, ≥ 15 mm) were screened for sputum smear-positive pulmonary tuberculosis. The percentage detection of tuberculosis in close contacts was compared between TST categories. RESULTS: We identified 433 close contacts of the 90 schoolchildren, who were then evaluated for tuberculosis. We identified 11 cases of pulmonary tuberculosis among the close contacts (7 already on treatment and 4 previously undiagnosed): 0 in TST category ≤ 5 mm, 3 in TST category [5-15) mm and 8 in TST category ≥ 15 mm). This approach increased the detection of tuberculosis cases by a factor of 1.6 in first-year schoolchildren of the TST ≥ 5 mm group. CONCLUSION: TST in first-year schoolchildren is a potentially effective method for improving the detection of tuberculosis in close contacts. |
| first_indexed | 2024-12-10T09:42:03Z |
| format | Article |
| id | doaj.art-3dd01c5afc654be68d26fbee8e738b65 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T09:42:03Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3dd01c5afc654be68d26fbee8e738b652022-12-22T01:53:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9549410.1371/journal.pone.0095494Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar.Rila RatovosonVoamalala RaharimangaNiaina RakotosamimananaB RavalosonMaherisosa RatsitorahinaRindra RandremananaHerimanana RamarokotoSoatiana RajatonirinaVoahangy RasolofoVincent RichardBACKGROUND: Tuberculosis continues to cause unacceptably high levels of disease and death worldwide. Active preventive strategies are required to improve tuberculosis control and to increase the number of cases treated in developing countries. The aim of this study was to evaluate the utility of the tuberculin skin test (TST) in first-year schoolchildren as a means of increasing the number of tuberculosis cases detected through the screening of close contacts. METHODS: All members of the households of 90 schoolchildren assigned to three groups on the basis of TST category (≤ 5 mm, [5-15)mm, ≥ 15 mm) were screened for sputum smear-positive pulmonary tuberculosis. The percentage detection of tuberculosis in close contacts was compared between TST categories. RESULTS: We identified 433 close contacts of the 90 schoolchildren, who were then evaluated for tuberculosis. We identified 11 cases of pulmonary tuberculosis among the close contacts (7 already on treatment and 4 previously undiagnosed): 0 in TST category ≤ 5 mm, 3 in TST category [5-15) mm and 8 in TST category ≥ 15 mm). This approach increased the detection of tuberculosis cases by a factor of 1.6 in first-year schoolchildren of the TST ≥ 5 mm group. CONCLUSION: TST in first-year schoolchildren is a potentially effective method for improving the detection of tuberculosis in close contacts.http://europepmc.org/articles/PMC3990634?pdf=render |
| spellingShingle | Rila Ratovoson Voamalala Raharimanga Niaina Rakotosamimanana B Ravaloson Maherisosa Ratsitorahina Rindra Randremanana Herimanana Ramarokoto Soatiana Rajatonirina Voahangy Rasolofo Vincent Richard Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar. PLoS ONE |
| title | Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar. |
| title_full | Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar. |
| title_fullStr | Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar. |
| title_full_unstemmed | Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar. |
| title_short | Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar. |
| title_sort | increase in the number of tuberculosis cases treated following tuberculin skin testing in first year schoolchildren in madagascar |
| url | http://europepmc.org/articles/PMC3990634?pdf=render |
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