COVID-19 incidence and outcomes among patients with kidney replacement therapy

Background We aimed to investigate the incidence, fatality, and associated factors in patients with hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) hospitalized for coronavirus disease 2019 (COVID-19) infection and reimbursed from the National Health Security Office (NHS...

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Main Authors: Siribha Changsirikulchai, Pornpen Sangthawan, Jirayut Janma, Songyos Rajborirug, Thammasin Ingviya
Format: Article
Language:English
Published: The Korean Society of Nephrology 2023-09-01
Series:Kidney Research and Clinical Practice
Subjects:
Online Access:http://krcp-ksn.org/upload/pdf/j-krcp-22-240.pdf
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author Siribha Changsirikulchai
Pornpen Sangthawan
Jirayut Janma
Songyos Rajborirug
Thammasin Ingviya
author_facet Siribha Changsirikulchai
Pornpen Sangthawan
Jirayut Janma
Songyos Rajborirug
Thammasin Ingviya
author_sort Siribha Changsirikulchai
collection DOAJ
description Background We aimed to investigate the incidence, fatality, and associated factors in patients with hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) hospitalized for coronavirus disease 2019 (COVID-19) infection and reimbursed from the National Health Security Office (NHSO). Methods The retrospective cohort analysis was conducted from an electronic-claimed database, and COVID-19 vaccination status was evaluated in patients with HD, PD, and KT from January 2020 to December 2021. There were 85,305 patients reimbursed for HD, PD, and KT by the NHSO. The rates of COVID-19 infection, COVID-19 vaccination, comorbidities, fatalities, and the cost of treatment were evaluated. Results COVID-19 infection was observed in 1,799 of 36,982 HD cases (4.9%), 1,531 of 45,453 PD cases (3.4%), and 95 of 2,870 KT cases (3.3%). Patients receiving COVID-19 vaccinations were most common in the KT group, followed by those with HD and PD (76.93% vs. 70.65% vs. 51.34%, respectively). KT patients had a lower fatality rate compared to those with PD and HD (8.42% vs. 18.41% vs. 21.40%, respectively). Advanced age, diabetes, cardiovascular diseases, and COVID-19 vaccination status were associated with fatality. The adjusted odds ratios of fatality after receiving one or two doses of vaccines were 0.7 (95% confidence interval [CI], 0.6–0.9) and 0.3 (95% CI, 0.2–0.4), respectively. The cost of treatment was highest in patients with HD, followed by PD and KT. Conclusion The incidence of COVID-19 infection was higher in patients with HD than in those with PD or KT. COVID-19 vaccination following the national health policy should be encouraged for these patients to prevent fatality.
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spelling doaj.art-3dd05c5514fc4864a1922c5cacff96f42023-11-14T07:03:34ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402023-09-0142564965910.23876/j.krcp.22.2406270COVID-19 incidence and outcomes among patients with kidney replacement therapySiribha Changsirikulchai0Pornpen Sangthawan1Jirayut Janma2Songyos Rajborirug3Thammasin Ingviya4 Division of Nephrology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhonnayok, Thailand Division of Nephrology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Division of Nephrology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhonnayok, Thailand Department of Epidemiology, Faculty of Medicine, Prince of Songkhla University, Songkhla, Thailand Department of Family and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandBackground We aimed to investigate the incidence, fatality, and associated factors in patients with hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) hospitalized for coronavirus disease 2019 (COVID-19) infection and reimbursed from the National Health Security Office (NHSO). Methods The retrospective cohort analysis was conducted from an electronic-claimed database, and COVID-19 vaccination status was evaluated in patients with HD, PD, and KT from January 2020 to December 2021. There were 85,305 patients reimbursed for HD, PD, and KT by the NHSO. The rates of COVID-19 infection, COVID-19 vaccination, comorbidities, fatalities, and the cost of treatment were evaluated. Results COVID-19 infection was observed in 1,799 of 36,982 HD cases (4.9%), 1,531 of 45,453 PD cases (3.4%), and 95 of 2,870 KT cases (3.3%). Patients receiving COVID-19 vaccinations were most common in the KT group, followed by those with HD and PD (76.93% vs. 70.65% vs. 51.34%, respectively). KT patients had a lower fatality rate compared to those with PD and HD (8.42% vs. 18.41% vs. 21.40%, respectively). Advanced age, diabetes, cardiovascular diseases, and COVID-19 vaccination status were associated with fatality. The adjusted odds ratios of fatality after receiving one or two doses of vaccines were 0.7 (95% confidence interval [CI], 0.6–0.9) and 0.3 (95% CI, 0.2–0.4), respectively. The cost of treatment was highest in patients with HD, followed by PD and KT. Conclusion The incidence of COVID-19 infection was higher in patients with HD than in those with PD or KT. COVID-19 vaccination following the national health policy should be encouraged for these patients to prevent fatality.http://krcp-ksn.org/upload/pdf/j-krcp-22-240.pdfcovid-19dialysiskidney transplantationperitoneal dialysisrenal dialysisrenal replacement therapy
spellingShingle Siribha Changsirikulchai
Pornpen Sangthawan
Jirayut Janma
Songyos Rajborirug
Thammasin Ingviya
COVID-19 incidence and outcomes among patients with kidney replacement therapy
Kidney Research and Clinical Practice
covid-19
dialysis
kidney transplantation
peritoneal dialysis
renal dialysis
renal replacement therapy
title COVID-19 incidence and outcomes among patients with kidney replacement therapy
title_full COVID-19 incidence and outcomes among patients with kidney replacement therapy
title_fullStr COVID-19 incidence and outcomes among patients with kidney replacement therapy
title_full_unstemmed COVID-19 incidence and outcomes among patients with kidney replacement therapy
title_short COVID-19 incidence and outcomes among patients with kidney replacement therapy
title_sort covid 19 incidence and outcomes among patients with kidney replacement therapy
topic covid-19
dialysis
kidney transplantation
peritoneal dialysis
renal dialysis
renal replacement therapy
url http://krcp-ksn.org/upload/pdf/j-krcp-22-240.pdf
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AT songyosrajborirug covid19incidenceandoutcomesamongpatientswithkidneyreplacementtherapy
AT thammasiningviya covid19incidenceandoutcomesamongpatientswithkidneyreplacementtherapy