Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks
In the present study, we determined the effects of oral administration of L- and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L- and D-Asp in the brain and plasma. Chicks were orally administered different...
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| Format: | Article |
| Language: | English |
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Japan Poultry Science Association
2013-04-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/50/2/50_0120116/_pdf/-char/en |
| _version_ | 1797816171964137472 |
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| author | Edi Erwan Shozo Tomonaga Taketo Ohmori Yuta Mutaguchi Toshihisa Ohshima Mao Nagasawa Shinobu Yasuo Yoshinaga Tamura Mitsuhiro Furuse |
| author_facet | Edi Erwan Shozo Tomonaga Taketo Ohmori Yuta Mutaguchi Toshihisa Ohshima Mao Nagasawa Shinobu Yasuo Yoshinaga Tamura Mitsuhiro Furuse |
| author_sort | Edi Erwan |
| collection | DOAJ |
| description | In the present study, we determined the effects of oral administration of L- and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L- and D-Asp in the brain and plasma. Chicks were orally administered different levels (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-Asp (Experiment 1) and D-Asp (Experiment 2). Administration of several doses of L-Asp linearly increased the concentration of L-Asp, but not of D-Asp, in plasma. Oral L-Asp somewhat modified the levels of L- and D-Asp levels in the telencephalon, but not in the diencephalon. However, food intake was not significantly changed with doses of L-Asp. On the other hand, D-Asp strongly and dose-dependently inhibited food intake over a period of 2 h after the administration. Oral D-Asp clearly increased D-Asp levels in the plasma and diencephalon, but no significant changes in L-Asp were detected. Brain monoamine contents were only minimally influenced by L- or D-Asp administration. We conclude that D-Asp may act as an anorexigenic factor in the diencephalon. |
| first_indexed | 2024-03-13T08:33:45Z |
| format | Article |
| id | doaj.art-3dd11eafe2824d9db609ddf60d767147 |
| institution | Directory Open Access Journal |
| issn | 1346-7395 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:33:45Z |
| publishDate | 2013-04-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-3dd11eafe2824d9db609ddf60d7671472023-05-31T01:23:33ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862013-04-0150216417110.2141/jpsa.0120116jpsaOral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in ChicksEdi Erwan0Shozo Tomonaga1Taketo Ohmori2Yuta Mutaguchi3Toshihisa Ohshima4Mao Nagasawa5Shinobu Yasuo6Yoshinaga Tamura7Mitsuhiro Furuse8Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanLaboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanMicrobial Genetic Division, Institute of Genetic Resources, Faculty of Agriculture, Kyushu University, JapanMicrobial Genetic Division, Institute of Genetic Resources, Faculty of Agriculture, Kyushu University, JapanMicrobial Genetic Division, Institute of Genetic Resources, Faculty of Agriculture, Kyushu University, JapanLaboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanLaboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanAsahi Kasei Chemicals Corporation, JapanLaboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanIn the present study, we determined the effects of oral administration of L- and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L- and D-Asp in the brain and plasma. Chicks were orally administered different levels (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-Asp (Experiment 1) and D-Asp (Experiment 2). Administration of several doses of L-Asp linearly increased the concentration of L-Asp, but not of D-Asp, in plasma. Oral L-Asp somewhat modified the levels of L- and D-Asp levels in the telencephalon, but not in the diencephalon. However, food intake was not significantly changed with doses of L-Asp. On the other hand, D-Asp strongly and dose-dependently inhibited food intake over a period of 2 h after the administration. Oral D-Asp clearly increased D-Asp levels in the plasma and diencephalon, but no significant changes in L-Asp were detected. Brain monoamine contents were only minimally influenced by L- or D-Asp administration. We conclude that D-Asp may act as an anorexigenic factor in the diencephalon.https://www.jstage.jst.go.jp/article/jpsa/50/2/50_0120116/_pdf/-char/enbraind-aspartatefood intakel-aspartateneonatal chickplasma |
| spellingShingle | Edi Erwan Shozo Tomonaga Taketo Ohmori Yuta Mutaguchi Toshihisa Ohshima Mao Nagasawa Shinobu Yasuo Yoshinaga Tamura Mitsuhiro Furuse Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks The Journal of Poultry Science brain d-aspartate food intake l-aspartate neonatal chick plasma |
| title | Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks |
| title_full | Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks |
| title_fullStr | Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks |
| title_full_unstemmed | Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks |
| title_short | Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks |
| title_sort | oral administration of d aspartate but not of l aspartate reduces food intake in chicks |
| topic | brain d-aspartate food intake l-aspartate neonatal chick plasma |
| url | https://www.jstage.jst.go.jp/article/jpsa/50/2/50_0120116/_pdf/-char/en |
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