Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging
The majority of atherothrombotic events (e.g., cerebral or myocardial infarction) often occur as a result of plaque rupture or erosion in the carotid, and thereby it is urgent to assess plaque vulnerability and predict adverse cerebrovascular events. However, the monitoring evolution from stable pla...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2023-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0186 |
| _version_ | 1827331118336049152 |
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| author | Li Xu Zhe Li Yuan Ma Lingling Lei Renye Yue Hui Cao Shuangyan Huan Wei Sun Guosheng Song |
| author_facet | Li Xu Zhe Li Yuan Ma Lingling Lei Renye Yue Hui Cao Shuangyan Huan Wei Sun Guosheng Song |
| author_sort | Li Xu |
| collection | DOAJ |
| description | The majority of atherothrombotic events (e.g., cerebral or myocardial infarction) often occur as a result of plaque rupture or erosion in the carotid, and thereby it is urgent to assess plaque vulnerability and predict adverse cerebrovascular events. However, the monitoring evolution from stable plaque into life-threatening high-risk plaque in the slender carotid artery is a great challenge, due to not enough spatial resolution for imaging the carotid artery based on most of reported fluorescent probes. Herein, copolymerizing with the small molecules of acceptor-donor-acceptor-donor-acceptor (A-D-A′-D-A) and the electron-donating units (D′), the screened second near-infrared (NIR-II) nanoprobe presents high quantum yield and good stability, so that it enables to image slender carotid vessel with enough spatial resolution. Encouragingly, NIR-II nanoprobe can effectively target to intraplaque macrophage, meanwhile distinguishing vulnerable plaque in carotid atherosclerosis in living mice. Moreover, the NIR-II nanoprobe can dynamically monitor the fresh bleeding spots in carotid plaque, indicating the increased risk of plaque instability. Besides, magnetic resonance imaging is integrated with NIR-II fluorescence imaging to provide contrast for subtle structure (e.g., narrow lumen and lipid pool), via incorporating ultrasmall superparamagnetic iron oxide into the NIR-II nanoprobe. Thus, such hybrid NIR-II/magnetic resonance imaging multimodal nanoprobe provides an effective tool for assessing carotid plaque burden, selecting high-risk plaque, and imaging intraplaque hemorrhage, which is promising for reducing cerebral/ myocardial infarction-associated morbidity and mortality. |
| first_indexed | 2024-03-07T16:30:21Z |
| format | Article |
| id | doaj.art-3dd27b414a004d9590b5030d2721b033 |
| institution | Directory Open Access Journal |
| issn | 2639-5274 |
| language | English |
| last_indexed | 2024-03-07T16:30:21Z |
| publishDate | 2023-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj.art-3dd27b414a004d9590b5030d2721b0332024-03-03T11:22:05ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742023-01-01610.34133/research.0186Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance ImagingLi Xu0Zhe Li1Yuan Ma2Lingling Lei3Renye Yue4Hui Cao5Shuangyan Huan6Wei Sun7Guosheng Song8State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing, Medical University.State Key Laboratory for Chemo/ Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering, Hunan University, Changsha 410082, China.The majority of atherothrombotic events (e.g., cerebral or myocardial infarction) often occur as a result of plaque rupture or erosion in the carotid, and thereby it is urgent to assess plaque vulnerability and predict adverse cerebrovascular events. However, the monitoring evolution from stable plaque into life-threatening high-risk plaque in the slender carotid artery is a great challenge, due to not enough spatial resolution for imaging the carotid artery based on most of reported fluorescent probes. Herein, copolymerizing with the small molecules of acceptor-donor-acceptor-donor-acceptor (A-D-A′-D-A) and the electron-donating units (D′), the screened second near-infrared (NIR-II) nanoprobe presents high quantum yield and good stability, so that it enables to image slender carotid vessel with enough spatial resolution. Encouragingly, NIR-II nanoprobe can effectively target to intraplaque macrophage, meanwhile distinguishing vulnerable plaque in carotid atherosclerosis in living mice. Moreover, the NIR-II nanoprobe can dynamically monitor the fresh bleeding spots in carotid plaque, indicating the increased risk of plaque instability. Besides, magnetic resonance imaging is integrated with NIR-II fluorescence imaging to provide contrast for subtle structure (e.g., narrow lumen and lipid pool), via incorporating ultrasmall superparamagnetic iron oxide into the NIR-II nanoprobe. Thus, such hybrid NIR-II/magnetic resonance imaging multimodal nanoprobe provides an effective tool for assessing carotid plaque burden, selecting high-risk plaque, and imaging intraplaque hemorrhage, which is promising for reducing cerebral/ myocardial infarction-associated morbidity and mortality.https://spj.science.org/doi/10.34133/research.0186 |
| spellingShingle | Li Xu Zhe Li Yuan Ma Lingling Lei Renye Yue Hui Cao Shuangyan Huan Wei Sun Guosheng Song Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging Research |
| title | Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging |
| title_full | Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging |
| title_fullStr | Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging |
| title_full_unstemmed | Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging |
| title_short | Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging |
| title_sort | imaging carotid plaque burden in living mice via hybrid semiconducting polymer nanoparticles based near infrared ii fluorescence and magnetic resonance imaging |
| url | https://spj.science.org/doi/10.34133/research.0186 |
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