MAFLD and NAFLD in the prediction of incident chronic kidney disease
Abstract Whether metabolic dysfunction-associated fatty liver disease (MAFLD) can replace nonalcoholic fatty liver disease (NAFLD) is under debate. This study evaluated which definition better predicted incident chronic kidney disease (CKD). This was a 5.3-year (range, 2.8–8.3) retrospective cohort...
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| Format: | Article |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-27762-6 |
| _version_ | 1811171749762433024 |
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| author | So Yoon Kwon Jiyun Park So Hee Park You-Bin Lee Gyuri Kim Kyu Yeon Hur Janghyun Koh Jae Hwan Jee Jae Hyeon Kim Mira Kang Sang-Man Jin |
| author_facet | So Yoon Kwon Jiyun Park So Hee Park You-Bin Lee Gyuri Kim Kyu Yeon Hur Janghyun Koh Jae Hwan Jee Jae Hyeon Kim Mira Kang Sang-Man Jin |
| author_sort | So Yoon Kwon |
| collection | DOAJ |
| description | Abstract Whether metabolic dysfunction-associated fatty liver disease (MAFLD) can replace nonalcoholic fatty liver disease (NAFLD) is under debate. This study evaluated which definition better predicted incident chronic kidney disease (CKD). This was a 5.3-year (range, 2.8–8.3) retrospective cohort study of 21,713 adults who underwent at least two serial health examinations. Cox analyses were used to compare the risk of incident CKD among non-fatty liver disease (FLD) without metabolic dysregulation (MD; reference), non-FLD with MD, MAFLD-only, NAFLD-only, or both-FLD groups. Non-FLD with MD group (hazard ratio [HR] 1.23, 95% confidence interval [CI] 1.00–1.53), both-FLD group (HR 1.50, 95% CI 1.19–1.89), and MAFLD-only group (HR 1.97, 95% CI 1.49–2.60), but not NAFLD-only group (HR 1.06, 95% CI 0.63–1.79) demonstrated an increased risk of CKD. The increased risk of CKD was significant in MAFLD subgroups with overweight/obesity (HR 2.94, 95% CI 1.91–4.55), diabetes (HR 2.20, 95% CI 1.67–2.90), MD only (HR 1.50, 95% CI 1.19–1.89), excessive alcohol consumption (HR 2.71, 95% CI 2.11–3.47), and viral hepatitis (HR 2.38, 95% CI 1.48–3.84). The switch from NAFLD to MAFLD criteria may identify a greater number of individuals at CKD risk. The association was also significant in MAFLD patients with excessive alcohol consumption or viral hepatitis. |
| first_indexed | 2024-04-10T17:19:13Z |
| format | Article |
| id | doaj.art-3dd467a4ef084477a3a612613f9906dd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T17:19:13Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3dd467a4ef084477a3a612613f9906dd2023-02-05T12:11:05ZengNature PortfolioScientific Reports2045-23222023-01-011311910.1038/s41598-023-27762-6MAFLD and NAFLD in the prediction of incident chronic kidney diseaseSo Yoon Kwon0Jiyun Park1So Hee Park2You-Bin Lee3Gyuri Kim4Kyu Yeon Hur5Janghyun Koh6Jae Hwan Jee7Jae Hyeon Kim8Mira Kang9Sang-Man Jin10Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrine and Metabolism, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of MedicineDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Health Promotion Center, Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Health Promotion Center, Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Health Promotion Center, Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract Whether metabolic dysfunction-associated fatty liver disease (MAFLD) can replace nonalcoholic fatty liver disease (NAFLD) is under debate. This study evaluated which definition better predicted incident chronic kidney disease (CKD). This was a 5.3-year (range, 2.8–8.3) retrospective cohort study of 21,713 adults who underwent at least two serial health examinations. Cox analyses were used to compare the risk of incident CKD among non-fatty liver disease (FLD) without metabolic dysregulation (MD; reference), non-FLD with MD, MAFLD-only, NAFLD-only, or both-FLD groups. Non-FLD with MD group (hazard ratio [HR] 1.23, 95% confidence interval [CI] 1.00–1.53), both-FLD group (HR 1.50, 95% CI 1.19–1.89), and MAFLD-only group (HR 1.97, 95% CI 1.49–2.60), but not NAFLD-only group (HR 1.06, 95% CI 0.63–1.79) demonstrated an increased risk of CKD. The increased risk of CKD was significant in MAFLD subgroups with overweight/obesity (HR 2.94, 95% CI 1.91–4.55), diabetes (HR 2.20, 95% CI 1.67–2.90), MD only (HR 1.50, 95% CI 1.19–1.89), excessive alcohol consumption (HR 2.71, 95% CI 2.11–3.47), and viral hepatitis (HR 2.38, 95% CI 1.48–3.84). The switch from NAFLD to MAFLD criteria may identify a greater number of individuals at CKD risk. The association was also significant in MAFLD patients with excessive alcohol consumption or viral hepatitis.https://doi.org/10.1038/s41598-023-27762-6 |
| spellingShingle | So Yoon Kwon Jiyun Park So Hee Park You-Bin Lee Gyuri Kim Kyu Yeon Hur Janghyun Koh Jae Hwan Jee Jae Hyeon Kim Mira Kang Sang-Man Jin MAFLD and NAFLD in the prediction of incident chronic kidney disease Scientific Reports |
| title | MAFLD and NAFLD in the prediction of incident chronic kidney disease |
| title_full | MAFLD and NAFLD in the prediction of incident chronic kidney disease |
| title_fullStr | MAFLD and NAFLD in the prediction of incident chronic kidney disease |
| title_full_unstemmed | MAFLD and NAFLD in the prediction of incident chronic kidney disease |
| title_short | MAFLD and NAFLD in the prediction of incident chronic kidney disease |
| title_sort | mafld and nafld in the prediction of incident chronic kidney disease |
| url | https://doi.org/10.1038/s41598-023-27762-6 |
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