ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin
The use of nanomaterials for the controlled release of drugs aims to enhance their effectiveness, especially when poorly soluble in water, and achieve their rapid, localized, and effective administration. The present study focuses on the use of a Zeolitic Imidazolate Framework-8 (ZIF-8) as vehicle f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2546 |
| _version_ | 1797464212765671424 |
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| author | Ventura Castillo Ramos Cinthia Berenice García Reyes Guillermo Mangas García María Inmaculada Sampedro Quesada Fernando José Martínez-Checa Barrero Jacob Josafat Salazar Rábago Manuel Sánchez Polo |
| author_facet | Ventura Castillo Ramos Cinthia Berenice García Reyes Guillermo Mangas García María Inmaculada Sampedro Quesada Fernando José Martínez-Checa Barrero Jacob Josafat Salazar Rábago Manuel Sánchez Polo |
| author_sort | Ventura Castillo Ramos |
| collection | DOAJ |
| description | The use of nanomaterials for the controlled release of drugs aims to enhance their effectiveness, especially when poorly soluble in water, and achieve their rapid, localized, and effective administration. The present study focuses on the use of a Zeolitic Imidazolate Framework-8 (ZIF-8) as vehicle for the transport and controlled release of the antibiotic ciprofloxacin (CIP) as model due to its favorable physicochemical characteristics. The objective is to synthesize the ZIF-8 material loaded with CIP through encapsulation for subsequent release of the drug in neutral and acid physiological media. In addition, functionalization of the CIP/ZIF compound with magnetic nanoparticles (NP) was sought to increase its traceability through the possible use of magnetic fields. Characterizations by XRD, FT-IR, SEM-EDX, and TGA showed a satisfactory synthesis of both pure ZIF-8 and ciprofloxacin-loaded ZIF-8, with high crystallinity and thermal stability. The release profiles showed an abrupt initial release that stabilized over time. A much higher release (20–80% greater) was obtained in acid versus neutral pH in all cases, attributable to the collapse of the ZIF-8 structure in acid media. In addition, functionalization of the material with iron NPs did not affect the behavior of the system during drug release. Antimicrobial activity tests against <i>E. coli</i> and <i>S. aureus</i> showed that ZIF-8 per se exerts antimicrobial activity, while the compounds CIP/ZIF and magnetic CIP/ZIF increased the antimicrobial capacity of pure CIP by 10–20%. The ZIF-8 system has high potential as a drug carrier and release agent for the treatment of diseases, especially those that cause acidification of the cellular environment, achieving a rapid, localized, and targeted action with the possibility of achieving traceability of the system after its magnetic functionalization. |
| first_indexed | 2024-03-09T18:03:49Z |
| format | Article |
| id | doaj.art-3dd4da6a36ba46c99ed7173c714adee1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:03:49Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3dd4da6a36ba46c99ed7173c714adee12023-11-24T09:37:34ZengMDPI AGPharmaceutics1999-49232022-11-011411254610.3390/pharmaceutics14112546ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of CiprofloxacinVentura Castillo Ramos0Cinthia Berenice García Reyes1Guillermo Mangas García2María Inmaculada Sampedro Quesada3Fernando José Martínez-Checa Barrero4Jacob Josafat Salazar Rábago5Manuel Sánchez Polo6Department of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, SpainDepartment of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, SpainDepartment of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, SpainDepartment of Microbiology, Faculty of Pharmacy, University of Granada, 18071 Granada, SpainDepartment of Microbiology, Faculty of Pharmacy, University of Granada, 18071 Granada, SpainFaculty of Chemical Sciences, Nuevo León Autonomous University, San Nicolás de los Garza 66455, MexicoDepartment of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, SpainThe use of nanomaterials for the controlled release of drugs aims to enhance their effectiveness, especially when poorly soluble in water, and achieve their rapid, localized, and effective administration. The present study focuses on the use of a Zeolitic Imidazolate Framework-8 (ZIF-8) as vehicle for the transport and controlled release of the antibiotic ciprofloxacin (CIP) as model due to its favorable physicochemical characteristics. The objective is to synthesize the ZIF-8 material loaded with CIP through encapsulation for subsequent release of the drug in neutral and acid physiological media. In addition, functionalization of the CIP/ZIF compound with magnetic nanoparticles (NP) was sought to increase its traceability through the possible use of magnetic fields. Characterizations by XRD, FT-IR, SEM-EDX, and TGA showed a satisfactory synthesis of both pure ZIF-8 and ciprofloxacin-loaded ZIF-8, with high crystallinity and thermal stability. The release profiles showed an abrupt initial release that stabilized over time. A much higher release (20–80% greater) was obtained in acid versus neutral pH in all cases, attributable to the collapse of the ZIF-8 structure in acid media. In addition, functionalization of the material with iron NPs did not affect the behavior of the system during drug release. Antimicrobial activity tests against <i>E. coli</i> and <i>S. aureus</i> showed that ZIF-8 per se exerts antimicrobial activity, while the compounds CIP/ZIF and magnetic CIP/ZIF increased the antimicrobial capacity of pure CIP by 10–20%. The ZIF-8 system has high potential as a drug carrier and release agent for the treatment of diseases, especially those that cause acidification of the cellular environment, achieving a rapid, localized, and targeted action with the possibility of achieving traceability of the system after its magnetic functionalization.https://www.mdpi.com/1999-4923/14/11/2546metal organic frameworksmagnetic ZIF-8drug releaseciprofloxacinpharmaceutical |
| spellingShingle | Ventura Castillo Ramos Cinthia Berenice García Reyes Guillermo Mangas García María Inmaculada Sampedro Quesada Fernando José Martínez-Checa Barrero Jacob Josafat Salazar Rábago Manuel Sánchez Polo ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin Pharmaceutics metal organic frameworks magnetic ZIF-8 drug release ciprofloxacin pharmaceutical |
| title | ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin |
| title_full | ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin |
| title_fullStr | ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin |
| title_full_unstemmed | ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin |
| title_short | ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin |
| title_sort | zif 8 and its magnetic functionalization as vehicle for the transport and release of ciprofloxacin |
| topic | metal organic frameworks magnetic ZIF-8 drug release ciprofloxacin pharmaceutical |
| url | https://www.mdpi.com/1999-4923/14/11/2546 |
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