Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute
Introduction: Anorectal malignant melanoma (ARMM) is an aggressive malignancy with dismal prognosis and a 5-year survival rate less than 20% in most of the previous studies. The ideal surgical treatment has still remained controversial. This retrospective study aims at analysing the outcome in patie...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Cancer Treatment and Research Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294221001131 |
| _version_ | 1819009471236538368 |
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| author | Viswanth Kottakota Vikas Warikoo Ajay Kumar Yadav Abhijeet Salunke Abhishek Jain Mohit Sharma Supreet Bhatt Ketul Puj Shashank Pandya |
| author_facet | Viswanth Kottakota Vikas Warikoo Ajay Kumar Yadav Abhijeet Salunke Abhishek Jain Mohit Sharma Supreet Bhatt Ketul Puj Shashank Pandya |
| author_sort | Viswanth Kottakota |
| collection | DOAJ |
| description | Introduction: Anorectal malignant melanoma (ARMM) is an aggressive malignancy with dismal prognosis and a 5-year survival rate less than 20% in most of the previous studies. The ideal surgical treatment has still remained controversial. This retrospective study aims at analysing the outcome in patients with ARMM treated with curative surgical resection. Patients and methods: This is a retrospective study of 38 patients of stage I anorectal malignant melanoma treated with curative surgical resection at our tertiary cancer institute. Results: WLE (Wide Local Excision) was carried out in 12 patients and APR (abdominoperineal resection) was done in 26 patients. The median overall survival of the entire group in this study was 20 months. Although the median overall survival of WLE patients was higher than those with APR (37 months versus 16 months, respectively), this was not a statistically significant event (P=0.317). The 1-, 2-, 3-, 5-year survival rates were similar with both APR and WLE with no significant difference in the 5-year survival rate (P=0.816); overall 5-year survival rate of just 13%. There were 3 long-term survivors in this study group who survived for more than 10 years. Conclusion: Most patients ultimately succumb to the disease regardless of the management. Both APR and WLE have significant roles in the management depending on the subset of patients selected. Local treatment should be preferred wherever possible. Abdominoperineal resection should be offered in nodal disease or in a recurrent setting. |
| first_indexed | 2024-12-21T00:56:54Z |
| format | Article |
| id | doaj.art-3dd69b62af564e53ac60b0fd51a9780e |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-12-21T00:56:54Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-3dd69b62af564e53ac60b0fd51a9780e2022-12-21T19:21:16ZengElsevierCancer Treatment and Research Communications2468-29422021-01-0128100415Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer instituteViswanth Kottakota0Vikas Warikoo1Ajay Kumar Yadav2Abhijeet Salunke3Abhishek Jain4Mohit Sharma5Supreet Bhatt6Ketul Puj7Shashank Pandya8Corresponding author.; Department of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaDepartment of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, IndiaIntroduction: Anorectal malignant melanoma (ARMM) is an aggressive malignancy with dismal prognosis and a 5-year survival rate less than 20% in most of the previous studies. The ideal surgical treatment has still remained controversial. This retrospective study aims at analysing the outcome in patients with ARMM treated with curative surgical resection. Patients and methods: This is a retrospective study of 38 patients of stage I anorectal malignant melanoma treated with curative surgical resection at our tertiary cancer institute. Results: WLE (Wide Local Excision) was carried out in 12 patients and APR (abdominoperineal resection) was done in 26 patients. The median overall survival of the entire group in this study was 20 months. Although the median overall survival of WLE patients was higher than those with APR (37 months versus 16 months, respectively), this was not a statistically significant event (P=0.317). The 1-, 2-, 3-, 5-year survival rates were similar with both APR and WLE with no significant difference in the 5-year survival rate (P=0.816); overall 5-year survival rate of just 13%. There were 3 long-term survivors in this study group who survived for more than 10 years. Conclusion: Most patients ultimately succumb to the disease regardless of the management. Both APR and WLE have significant roles in the management depending on the subset of patients selected. Local treatment should be preferred wherever possible. Abdominoperineal resection should be offered in nodal disease or in a recurrent setting.http://www.sciencedirect.com/science/article/pii/S2468294221001131Anorectal melanomaAbdominoperineal resectionWide local excisionMelanoma surgeryMelanoma survival |
| spellingShingle | Viswanth Kottakota Vikas Warikoo Ajay Kumar Yadav Abhijeet Salunke Abhishek Jain Mohit Sharma Supreet Bhatt Ketul Puj Shashank Pandya Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute Cancer Treatment and Research Communications Anorectal melanoma Abdominoperineal resection Wide local excision Melanoma surgery Melanoma survival |
| title | Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute |
| title_full | Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute |
| title_fullStr | Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute |
| title_full_unstemmed | Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute |
| title_short | Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute |
| title_sort | clinical and oncological outcomes of surgery in anorectal melanoma in asian population a 15 year analysis at a tertiary cancer institute |
| topic | Anorectal melanoma Abdominoperineal resection Wide local excision Melanoma surgery Melanoma survival |
| url | http://www.sciencedirect.com/science/article/pii/S2468294221001131 |
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