Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease
Background: The shape of the left ventricle (LV) is an important index to explore cardiac pathophysiology. A comparison was provided to estimate circumferential, longitudinal, and radial wall stress in LV based on the thick-walled ellipsoidal models of Mirsky and Ghista-Sandler for discriminating si...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2023;volume=28;issue=1;spage=62;epage=62;aulast=Ahmadi |
| _version_ | 1797738513777557504 |
|---|---|
| author | Zeinab Alsadat Ahmadi Manijhe Mokhtari Dizaji Anita Sadeghpour Hamideh Khesali Ata Firouzi |
| author_facet | Zeinab Alsadat Ahmadi Manijhe Mokhtari Dizaji Anita Sadeghpour Hamideh Khesali Ata Firouzi |
| author_sort | Zeinab Alsadat Ahmadi |
| collection | DOAJ |
| description | Background: The shape of the left ventricle (LV) is an important index to explore cardiac pathophysiology. A comparison was provided to estimate circumferential, longitudinal, and radial wall stress in LV based on the thick-walled ellipsoidal models of Mirsky and Ghista-Sandler for discriminating significant coronary artery disease (CAD) patients from no CAD patients. Materials and Methods: According to the angiography findings, 82 patients with CAD were divided into two groups: 25 patients without significant CAD and 57 patients with significant CAD of single vessel and multivessel. An ellipsoidal LV geometry was used to calculate end-systolic passive stress as the mechanical behavior of LV. Echocardiographic views-based measurements of LV diameters used to estimate the end-systolic wall stress. Results: Circumferential wall stress between the control group and significant CAD groups was significantly elevated for the Ghista model (P = 0.008); also, radial and longitudinal stress of the multi-vessel CAD group was significantly higher than the control group (P = 0.01 and P = 0.005, respectively). All stress parameters of the multi-vessel CAD group were statistically significant compared to the control group for the Mirsky model. Receiver operating characteristics curve analysis was shown the circumferential stress of multi-vessel CAD with an area under the curve (AUC) of 0.736 for the Ghista model and an AUC of 0.742 for the Mirsky model. Conclusion: These results indicated that Ghista and Mirsky model estimates of circumferential passive stress were the potential biomechanical markers to predict patients with multi-vessel CAD. It could be a noninvasive and helpful tool to quantify the contractility of LV. |
| first_indexed | 2024-03-12T13:44:52Z |
| format | Article |
| id | doaj.art-3dd6b5a355b14896b1a23a0f1030623e |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-03-12T13:44:52Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-3dd6b5a355b14896b1a23a0f1030623e2023-08-23T09:43:21ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362023-01-01281626210.4103/jrms.jrms_4_21Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery diseaseZeinab Alsadat AhmadiManijhe Mokhtari DizajiAnita SadeghpourHamideh KhesaliAta FirouziBackground: The shape of the left ventricle (LV) is an important index to explore cardiac pathophysiology. A comparison was provided to estimate circumferential, longitudinal, and radial wall stress in LV based on the thick-walled ellipsoidal models of Mirsky and Ghista-Sandler for discriminating significant coronary artery disease (CAD) patients from no CAD patients. Materials and Methods: According to the angiography findings, 82 patients with CAD were divided into two groups: 25 patients without significant CAD and 57 patients with significant CAD of single vessel and multivessel. An ellipsoidal LV geometry was used to calculate end-systolic passive stress as the mechanical behavior of LV. Echocardiographic views-based measurements of LV diameters used to estimate the end-systolic wall stress. Results: Circumferential wall stress between the control group and significant CAD groups was significantly elevated for the Ghista model (P = 0.008); also, radial and longitudinal stress of the multi-vessel CAD group was significantly higher than the control group (P = 0.01 and P = 0.005, respectively). All stress parameters of the multi-vessel CAD group were statistically significant compared to the control group for the Mirsky model. Receiver operating characteristics curve analysis was shown the circumferential stress of multi-vessel CAD with an area under the curve (AUC) of 0.736 for the Ghista model and an AUC of 0.742 for the Mirsky model. Conclusion: These results indicated that Ghista and Mirsky model estimates of circumferential passive stress were the potential biomechanical markers to predict patients with multi-vessel CAD. It could be a noninvasive and helpful tool to quantify the contractility of LV.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2023;volume=28;issue=1;spage=62;epage=62;aulast=Ahmadiellipsoidal modelthick walledwall stress |
| spellingShingle | Zeinab Alsadat Ahmadi Manijhe Mokhtari Dizaji Anita Sadeghpour Hamideh Khesali Ata Firouzi Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease Journal of Research in Medical Sciences ellipsoidal model thick walled wall stress |
| title | Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease |
| title_full | Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease |
| title_fullStr | Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease |
| title_full_unstemmed | Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease |
| title_short | Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease |
| title_sort | comparison of two ellipsoidal models for the estimation of left ventricular end systolic stress in patients with significant coronary artery disease |
| topic | ellipsoidal model thick walled wall stress |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2023;volume=28;issue=1;spage=62;epage=62;aulast=Ahmadi |
| work_keys_str_mv | AT zeinabalsadatahmadi comparisonoftwoellipsoidalmodelsfortheestimationofleftventricularendsystolicstressinpatientswithsignificantcoronaryarterydisease AT manijhemokhtaridizaji comparisonoftwoellipsoidalmodelsfortheestimationofleftventricularendsystolicstressinpatientswithsignificantcoronaryarterydisease AT anitasadeghpour comparisonoftwoellipsoidalmodelsfortheestimationofleftventricularendsystolicstressinpatientswithsignificantcoronaryarterydisease AT hamidehkhesali comparisonoftwoellipsoidalmodelsfortheestimationofleftventricularendsystolicstressinpatientswithsignificantcoronaryarterydisease AT atafirouzi comparisonoftwoellipsoidalmodelsfortheestimationofleftventricularendsystolicstressinpatientswithsignificantcoronaryarterydisease |