PEG Spacer Length Substantially Affects Antibody-Based Nanocarrier Targeting of Dendritic Cell Subsets

PEG Spacer Length Substantially Affects Antibody-Based Nanocarrier Targeting of Dendritic Cell Subsets

Successful cell targeting depends on the controlled positioning of cell-type-specific antibodies on the nanocarrier’s (NC) surface. Uncontrolled antibody immobilization results in unintended cell uptake due to Fc-mediated cell interaction. Consequently, precise immobilization of the Fc region toward...

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Bibliographic Details
Main Authors: Maximilian Brückner, Michael Fichter, Richard da Costa Marques, Katharina Landfester, Volker Mailänder
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
antibody functionalization
nanoparticles
nanovaccine
dendritic cell targeting
PEG
Online Access:https://www.mdpi.com/1999-4923/14/8/1614

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