Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine
Major depressive disorder is a serious disease that impacts human health worldwide. Traditional antidepressant medications are limited by the delayed onset of therapeutic effects and the unacceptable side effects. Recently, the rapid antidepressant effect of ketamine, which decreases depressive symp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Laboratory Animal and Comparative Medicine
2022-10-01
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| Series: | Shiyan dongwu yu bijiao yixue |
| Subjects: | |
| Online Access: | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2022.146 |
| _version_ | 1811179891387793408 |
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| author | WEI Sheng GENG Xiwen ZHAO Feng LI Zifa ZHANG Hao HU Minghui |
| author_facet | WEI Sheng GENG Xiwen ZHAO Feng LI Zifa ZHANG Hao HU Minghui |
| author_sort | WEI Sheng |
| collection | DOAJ |
| description | Major depressive disorder is a serious disease that impacts human health worldwide. Traditional antidepressant medications are limited by the delayed onset of therapeutic effects and the unacceptable side effects. Recently, the rapid antidepressant effect of ketamine, which decreases depressive symptoms within hours, has been a very attractive finding in the field, but the underlying mechanisms mediating this rapid response remain unclear. Besides, the clinical application of ketamine still carries risks, such as addiction and deleterious side effects. In May 2022, Rawat et al. reported that the acute activation of adult-born immature granule neurons (ABINs) in the dentate gyrus played a key role in the rapid antidepressant effects of ketamine. This commentary reviews the important findings of this research and looks forward to the future work. |
| first_indexed | 2024-04-11T06:41:18Z |
| format | Article |
| id | doaj.art-3ddd002cdbcd4a46a1b69bd13c288b38 |
| institution | Directory Open Access Journal |
| issn | 1674-5817 |
| language | zho |
| last_indexed | 2024-04-11T06:41:18Z |
| publishDate | 2022-10-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj.art-3ddd002cdbcd4a46a1b69bd13c288b382022-12-22T04:39:30ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172022-10-0142537738310.12300/j.issn.1674-5817.2022.1461674-5817（2022）05-0377-07Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of KetamineWEI ShengGENG XiwenZHAO FengLI ZifaZHANG HaoHU MinghuiMajor depressive disorder is a serious disease that impacts human health worldwide. Traditional antidepressant medications are limited by the delayed onset of therapeutic effects and the unacceptable side effects. Recently, the rapid antidepressant effect of ketamine, which decreases depressive symptoms within hours, has been a very attractive finding in the field, but the underlying mechanisms mediating this rapid response remain unclear. Besides, the clinical application of ketamine still carries risks, such as addiction and deleterious side effects. In May 2022, Rawat et al. reported that the acute activation of adult-born immature granule neurons (ABINs) in the dentate gyrus played a key role in the rapid antidepressant effects of ketamine. This commentary reviews the important findings of this research and looks forward to the future work.https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2022.146major depressive disorderketaminerapid antidepressant effectdentate gyrusadult-born immature granule neurons |
| spellingShingle | WEI Sheng GENG Xiwen ZHAO Feng LI Zifa ZHANG Hao HU Minghui Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine Shiyan dongwu yu bijiao yixue major depressive disorder ketamine rapid antidepressant effect dentate gyrus adult-born immature granule neurons |
| title | Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine |
| title_full | Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine |
| title_fullStr | Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine |
| title_full_unstemmed | Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine |
| title_short | Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine |
| title_sort | recent research progress of the mechanism of adult born immature granule neurons underlying rapid antidepressant effect of ketamine |
| topic | major depressive disorder ketamine rapid antidepressant effect dentate gyrus adult-born immature granule neurons |
| url | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2022.146 |
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