The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled study
Background and aim: Infectious disease (ID) consultation can improve multidrug-resistant organism (MDRO) treatment outcomes. However, the impact of clinical pharmacists’ ID consultation on MDRO therapy, especially early initiation, has not been reported. In this study, we try to explore the impact o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1128219/full |
| _version_ | 1811161899495063552 |
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| author | Qian Du Xin Xi Jie Dong Tongyan Zhang Dongxuan Li Dongxuan Li Yuzhu Dong Wenjun Li Guili Huang Jun Zhu Hailong Ran Jinghui Gou Cheng Chen Zhanfeng Bai Qinglong Liu Wei Yao Lei Zhang Yutian Bi Songqing Liu |
| author_facet | Qian Du Xin Xi Jie Dong Tongyan Zhang Dongxuan Li Dongxuan Li Yuzhu Dong Wenjun Li Guili Huang Jun Zhu Hailong Ran Jinghui Gou Cheng Chen Zhanfeng Bai Qinglong Liu Wei Yao Lei Zhang Yutian Bi Songqing Liu |
| author_sort | Qian Du |
| collection | DOAJ |
| description | Background and aim: Infectious disease (ID) consultation can improve multidrug-resistant organism (MDRO) treatment outcomes. However, the impact of clinical pharmacists’ ID consultation on MDRO therapy, especially early initiation, has not been reported. In this study, we try to explore the impact of the pharmacist early active consultation (PEAC) on MDRO patient management.Methods: We conducted a prospective historical controlled study based on PEAC in MDRO patients. The retrospective control group was patients hospitalized 18 months before the PEAC initiation, and the prospective PEAC group was patients hospitalized 18 months after the PEAC initiation. Primary endpoint was 30-day all-cause mortality. Secondary outcomes were MDRO clinical outcome, duration of antibiotic use, length of stay, antibiotic consumption and antibiotic costs. Further subgroup analysis of secondary outcomes was performed by the condition at admission, MDRO pathogenicity and MDRO clinical outcome.Results: 188 MDRO patients were included. After adjusting for potential predictors, PEAC reduced the 30-day all-cause mortality by 70% (HR 0.30, 95% CI 0.09–0.96, p = 0.042). PEAC group had clinical improvement than control group (89.47% vs. 65.59%, p < 0.001), especially in patients with non-severe clinical conditions at admission (98.41% vs. 70.18%, p < 0.001). However, no significant differences were found between groups in length of stay, antibiotics consumption, and antibiotics costs.Conclusion: Early active pharmacy ID consultation can reduce 30-day all-cause mortality and improve clinical outcomes in MDRO patients. |
| first_indexed | 2024-04-10T06:21:27Z |
| format | Article |
| id | doaj.art-3ddd4184a31e484ab9ac1716c56002ff |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T06:21:27Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3ddd4184a31e484ab9ac1716c56002ff2023-03-02T04:38:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.11282191128219The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled studyQian Du0Xin Xi1Jie Dong2Tongyan Zhang3Dongxuan Li4Dongxuan Li5Yuzhu Dong6Wenjun Li7Guili Huang8Jun Zhu9Hailong Ran10Jinghui Gou11Cheng Chen12Zhanfeng Bai13Qinglong Liu14Wei Yao15Lei Zhang16Yutian Bi17Songqing Liu18Department of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaInfectious Disease Department, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaCollege of Pharmacy, Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Intensive Care Unit, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Medical Administration, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackground and aim: Infectious disease (ID) consultation can improve multidrug-resistant organism (MDRO) treatment outcomes. However, the impact of clinical pharmacists’ ID consultation on MDRO therapy, especially early initiation, has not been reported. In this study, we try to explore the impact of the pharmacist early active consultation (PEAC) on MDRO patient management.Methods: We conducted a prospective historical controlled study based on PEAC in MDRO patients. The retrospective control group was patients hospitalized 18 months before the PEAC initiation, and the prospective PEAC group was patients hospitalized 18 months after the PEAC initiation. Primary endpoint was 30-day all-cause mortality. Secondary outcomes were MDRO clinical outcome, duration of antibiotic use, length of stay, antibiotic consumption and antibiotic costs. Further subgroup analysis of secondary outcomes was performed by the condition at admission, MDRO pathogenicity and MDRO clinical outcome.Results: 188 MDRO patients were included. After adjusting for potential predictors, PEAC reduced the 30-day all-cause mortality by 70% (HR 0.30, 95% CI 0.09–0.96, p = 0.042). PEAC group had clinical improvement than control group (89.47% vs. 65.59%, p < 0.001), especially in patients with non-severe clinical conditions at admission (98.41% vs. 70.18%, p < 0.001). However, no significant differences were found between groups in length of stay, antibiotics consumption, and antibiotics costs.Conclusion: Early active pharmacy ID consultation can reduce 30-day all-cause mortality and improve clinical outcomes in MDRO patients.https://www.frontiersin.org/articles/10.3389/fphar.2023.1128219/fullclinical pharmacistsinfective diseaseconsultationmultidrug-resistance organismearly intervention |
| spellingShingle | Qian Du Xin Xi Jie Dong Tongyan Zhang Dongxuan Li Dongxuan Li Yuzhu Dong Wenjun Li Guili Huang Jun Zhu Hailong Ran Jinghui Gou Cheng Chen Zhanfeng Bai Qinglong Liu Wei Yao Lei Zhang Yutian Bi Songqing Liu The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled study Frontiers in Pharmacology clinical pharmacists infective disease consultation multidrug-resistance organism early intervention |
| title | The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled study |
| title_full | The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled study |
| title_fullStr | The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled study |
| title_full_unstemmed | The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled study |
| title_short | The impact of pharmacist early active consultation (PEAC) on multidrug resistance organism treatment outcomes: A prospective historically controlled study |
| title_sort | impact of pharmacist early active consultation peac on multidrug resistance organism treatment outcomes a prospective historically controlled study |
| topic | clinical pharmacists infective disease consultation multidrug-resistance organism early intervention |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1128219/full |
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