COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness
The efficacy of vaccines against coronavirus disease 2019 (COVID-19) has now been well established in phase III clinical trials. However, clinical studies based on real-world data remain critical to assess vaccines effectiveness (VE), especially in specific populations and against variants of concer...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/14/10/2086 |
| _version_ | 1797469618351112192 |
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| author | Yousra Kherabi Odile Launay Liem Binh Luong Nguyen |
| author_facet | Yousra Kherabi Odile Launay Liem Binh Luong Nguyen |
| author_sort | Yousra Kherabi |
| collection | DOAJ |
| description | The efficacy of vaccines against coronavirus disease 2019 (COVID-19) has now been well established in phase III clinical trials. However, clinical studies based on real-world data remain critical to assess vaccines effectiveness (VE), especially in specific populations and against variants of concern (VOC). This review presents the principles and methods of VE studies and the main available results on VE of COVID-19 vaccines at the time of Omicron circulation. References for this narrative review were identified through searches of PubMed database up to 13 September 2022. The results of phase III clinical trials have been globally confirmed by VE in real-life studies, including in the elderly. Emergence of VOC Omicron emphasized the importance of booster doses to maintain a high level of protection against severe forms. There are still numerous challenges regarding booster(s) and duration of immunity, particularly in specific subpopulations, and regarding the need for adapted vaccines. |
| first_indexed | 2024-03-09T19:23:48Z |
| format | Article |
| id | doaj.art-3ddf254fe30e4e5aa46618748a5711e2 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T19:23:48Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3ddf254fe30e4e5aa46618748a5711e22023-11-24T03:07:10ZengMDPI AGViruses1999-49152022-09-011410208610.3390/v14102086COVID-19 Vaccines against Omicron Variant: Real-World Data on EffectivenessYousra Kherabi0Odile Launay1Liem Binh Luong Nguyen2Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Centre d’Investigation Clinique, 75014 Paris, FranceAssistance Publique Hôpitaux de Paris, Hôpital Cochin, Centre d’Investigation Clinique, 75014 Paris, FranceAssistance Publique Hôpitaux de Paris, Hôpital Cochin, Centre d’Investigation Clinique, 75014 Paris, FranceThe efficacy of vaccines against coronavirus disease 2019 (COVID-19) has now been well established in phase III clinical trials. However, clinical studies based on real-world data remain critical to assess vaccines effectiveness (VE), especially in specific populations and against variants of concern (VOC). This review presents the principles and methods of VE studies and the main available results on VE of COVID-19 vaccines at the time of Omicron circulation. References for this narrative review were identified through searches of PubMed database up to 13 September 2022. The results of phase III clinical trials have been globally confirmed by VE in real-life studies, including in the elderly. Emergence of VOC Omicron emphasized the importance of booster doses to maintain a high level of protection against severe forms. There are still numerous challenges regarding booster(s) and duration of immunity, particularly in specific subpopulations, and regarding the need for adapted vaccines.https://www.mdpi.com/1999-4915/14/10/2086COVID-19 vaccinesSARS-CoV-2omicroneffectiveness |
| spellingShingle | Yousra Kherabi Odile Launay Liem Binh Luong Nguyen COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness Viruses COVID-19 vaccines SARS-CoV-2 omicron effectiveness |
| title | COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness |
| title_full | COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness |
| title_fullStr | COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness |
| title_full_unstemmed | COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness |
| title_short | COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness |
| title_sort | covid 19 vaccines against omicron variant real world data on effectiveness |
| topic | COVID-19 vaccines SARS-CoV-2 omicron effectiveness |
| url | https://www.mdpi.com/1999-4915/14/10/2086 |
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