Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two Years Follow-Up
Inroduction: Heart failure (HF) is an important cause of morbidity and mortality in the cases of Beta-thalassemia major. The purpose of this study was to estimate HF prevalence in these patients and to assess the survivability of those who were treated with intensive chelating therapy. Design and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-05-01
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| Series: | Journal of Cardio-Thoracic Medicine |
| Subjects: | |
| Online Access: | http://jctm.mums.ac.ir/pdf_561_b75d9a45a26a2697105d4c41888486c8.html |
| _version_ | 1819036296593539072 |
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| author | Atooshe Rohani Vahid Akbari Mehdi Moradipoor Mehdi Akbartabar |
| author_facet | Atooshe Rohani Vahid Akbari Mehdi Moradipoor Mehdi Akbartabar |
| author_sort | Atooshe Rohani |
| collection | DOAJ |
| description | Inroduction: Heart failure (HF) is an important cause of morbidity and mortality in the cases of Beta-thalassemia major. The purpose of this study was to estimate HF prevalence in these patients and to assess the survivability of those who were treated with intensive chelating therapy. Design and methods: This cross sectional study included 72 beta-thalassemia major cases, the mean age at the time of referral was 15.7±6.2 years (range 6-35 years) and were followed in a prospective 2 year study. A self-reporting symptom questionnaire was administered, a 12-lead ECG was taken and an echocardiography was obtained from all participants. Echocardiography was performed at 6 month intervals or when a new symptom developed. Results: Risk factors (except for iron overload) in the study population were hypothyroidism and diabetes mellitus. The male to female ratio was0.75.Twelve patients had left ventricular (LV) systolic dysfunction and 57,79% had LV diastolic dysfunction whereas 11,15% had RV failure. Fifty-nine (81%) patients had cardiac disease of which diastolic dysfunction was the most common manifestation .Those with systolic dysfunction were older at presentation (22 ± 6 years versus 31 ± 4 years; P |
| first_indexed | 2024-12-21T08:03:16Z |
| format | Article |
| id | doaj.art-3ddfc6fcfcb44f5f83d9fc3c92b9bd81 |
| institution | Directory Open Access Journal |
| issn | 2345-2447 2322-5750 |
| language | English |
| last_indexed | 2024-12-21T08:03:16Z |
| publishDate | 2013-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardio-Thoracic Medicine |
| spelling | doaj.art-3ddfc6fcfcb44f5f83d9fc3c92b9bd812022-12-21T19:10:51ZengMashhad University of Medical SciencesJournal of Cardio-Thoracic Medicine2345-24472322-57502013-05-01111619561Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two Years Follow-UpAtooshe Rohani0Vahid Akbari1Mehdi Moradipoor2Mehdi Akbartabar3Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, IranCardiologist,17 Shahrivar Hospital,Mashhad,IranCardiologist ,Yasuj University of Medical Sciences, Yasuj, IranCardiologist ,Yasuj University of Medical Sciences, Yasuj, IranInroduction: Heart failure (HF) is an important cause of morbidity and mortality in the cases of Beta-thalassemia major. The purpose of this study was to estimate HF prevalence in these patients and to assess the survivability of those who were treated with intensive chelating therapy. Design and methods: This cross sectional study included 72 beta-thalassemia major cases, the mean age at the time of referral was 15.7±6.2 years (range 6-35 years) and were followed in a prospective 2 year study. A self-reporting symptom questionnaire was administered, a 12-lead ECG was taken and an echocardiography was obtained from all participants. Echocardiography was performed at 6 month intervals or when a new symptom developed. Results: Risk factors (except for iron overload) in the study population were hypothyroidism and diabetes mellitus. The male to female ratio was0.75.Twelve patients had left ventricular (LV) systolic dysfunction and 57,79% had LV diastolic dysfunction whereas 11,15% had RV failure. Fifty-nine (81%) patients had cardiac disease of which diastolic dysfunction was the most common manifestation .Those with systolic dysfunction were older at presentation (22 ± 6 years versus 31 ± 4 years; Phttp://jctm.mums.ac.ir/pdf_561_b75d9a45a26a2697105d4c41888486c8.htmlBeta-thalassemia major Cardiac abnormalities Tei-index |
| spellingShingle | Atooshe Rohani Vahid Akbari Mehdi Moradipoor Mehdi Akbartabar Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two Years Follow-Up Journal of Cardio-Thoracic Medicine Beta-thalassemia major Cardiac abnormalities Tei-index |
| title | Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two
Years Follow-Up |
| title_full | Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two
Years Follow-Up |
| title_fullStr | Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two
Years Follow-Up |
| title_full_unstemmed | Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two
Years Follow-Up |
| title_short | Prevalence of Heart Failure in the Cases of Beta-thalassemia Major; Two
Years Follow-Up |
| title_sort | prevalence of heart failure in the cases of beta thalassemia major two years follow up |
| topic | Beta-thalassemia major Cardiac abnormalities Tei-index |
| url | http://jctm.mums.ac.ir/pdf_561_b75d9a45a26a2697105d4c41888486c8.html |
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