Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose
Despite extensive technological advances in recent years, objective and continuous assessment of physiologic measures after vaccination is rarely performed. We conducted a prospective observational study to evaluate short-term self-reported and physiologic reactions to the booster BNT162b2 mRNA (Pf...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2022-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/7/21-2330_article |
| _version_ | 1811240834035613696 |
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| author | Merav Mofaz Matan Yechezkel Grace Guan Margaret L. Brandeau Tal Patalon Sivan Gazit Dan Yamin Erez Shmueli |
| author_facet | Merav Mofaz Matan Yechezkel Grace Guan Margaret L. Brandeau Tal Patalon Sivan Gazit Dan Yamin Erez Shmueli |
| author_sort | Merav Mofaz |
| collection | DOAJ |
| description |
Despite extensive technological advances in recent years, objective and continuous assessment of physiologic measures after vaccination is rarely performed. We conducted a prospective observational study to evaluate short-term self-reported and physiologic reactions to the booster BNT162b2 mRNA (Pfizer-BioNTech, https://www.pfizer.com) vaccine dose. A total of 1,609 participants were equipped with smartwatches and completed daily questionnaires through a dedicated mobile application. The extent of systemic reactions reported after the booster dose was similar to that of the second dose and considerably greater than that of the first dose. Analyses of objective heart rate and heart rate variability measures recorded by smartwatches further supported this finding. Subjective and objective reactions after the booster dose were more apparent in younger participants and in participants who did not have underlying medical conditions. Our findings further support the safety of the booster dose from subjective and objective perspectives and underscore the need for integrating wearables in clinical trials.
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| first_indexed | 2024-04-12T13:28:16Z |
| format | Article |
| id | doaj.art-3de28be28d6b4bac9ecac93cecf2e421 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T13:28:16Z |
| publishDate | 2022-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-3de28be28d6b4bac9ecac93cecf2e4212022-12-22T03:31:16ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-07-012871375138310.3201/eid2807.212330Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine DoseMerav MofazMatan YechezkelGrace GuanMargaret L. BrandeauTal PatalonSivan GazitDan YaminErez Shmueli Despite extensive technological advances in recent years, objective and continuous assessment of physiologic measures after vaccination is rarely performed. We conducted a prospective observational study to evaluate short-term self-reported and physiologic reactions to the booster BNT162b2 mRNA (Pfizer-BioNTech, https://www.pfizer.com) vaccine dose. A total of 1,609 participants were equipped with smartwatches and completed daily questionnaires through a dedicated mobile application. The extent of systemic reactions reported after the booster dose was similar to that of the second dose and considerably greater than that of the first dose. Analyses of objective heart rate and heart rate variability measures recorded by smartwatches further supported this finding. Subjective and objective reactions after the booster dose were more apparent in younger participants and in participants who did not have underlying medical conditions. Our findings further support the safety of the booster dose from subjective and objective perspectives and underscore the need for integrating wearables in clinical trials. https://wwwnc.cdc.gov/eid/article/28/7/21-2330_articleCOVID-19coronavirus diseasesevere acute respiratory syndrome coronavirus 2SARS-CoV-2virusescoronaviruses |
| spellingShingle | Merav Mofaz Matan Yechezkel Grace Guan Margaret L. Brandeau Tal Patalon Sivan Gazit Dan Yamin Erez Shmueli Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose Emerging Infectious Diseases COVID-19 coronavirus disease severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 viruses coronaviruses |
| title | Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose |
| title_full | Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose |
| title_fullStr | Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose |
| title_full_unstemmed | Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose |
| title_short | Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose |
| title_sort | self reported and physiologic reactions to third bnt162b2 mrna covid 19 booster vaccine dose |
| topic | COVID-19 coronavirus disease severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 viruses coronaviruses |
| url | https://wwwnc.cdc.gov/eid/article/28/7/21-2330_article |
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