Multiple Roles of PLK1 in Mitosis and Meiosis
Cells are equipped with a diverse network of signaling and regulatory proteins that function as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell division. A key regulator of cell division is polo-like kinase 1 (PLK1), a member of the serine/threonine kinase fami...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/1/187 |
| _version_ | 1797626025345024000 |
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| author | Jaroslav Kalous Daria Aleshkina |
| author_facet | Jaroslav Kalous Daria Aleshkina |
| author_sort | Jaroslav Kalous |
| collection | DOAJ |
| description | Cells are equipped with a diverse network of signaling and regulatory proteins that function as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell division. A key regulator of cell division is polo-like kinase 1 (PLK1), a member of the serine/threonine kinase family that plays an important role in regulating the mitotic and meiotic cell cycle. The phosphorylation of specific substrates mediated by PLK1 controls nuclear envelope breakdown (NEBD), centrosome maturation, proper spindle assembly, chromosome segregation, and cytokinesis. In mammalian oogenesis, PLK1 is essential for resuming meiosis before ovulation and for establishing the meiotic spindle. Among other potential roles, PLK1 regulates the localized translation of spindle-enriched mRNAs by phosphorylating and thereby inhibiting the translational repressor 4E-BP1, a downstream target of the mTOR (mammalian target of rapamycin) pathway. In this review, we summarize the functions of PLK1 in mitosis, meiosis, and cytokinesis and focus on the role of PLK1 in regulating mRNA translation. However, knowledge of the role of PLK1 in the regulation of meiosis remains limited. |
| first_indexed | 2024-03-11T10:04:45Z |
| format | Article |
| id | doaj.art-3de32c44f0ca4ce3bbcefd934b3c3f45 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T10:04:45Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3de32c44f0ca4ce3bbcefd934b3c3f452023-11-16T15:07:17ZengMDPI AGCells2073-44092023-01-0112118710.3390/cells12010187Multiple Roles of PLK1 in Mitosis and MeiosisJaroslav Kalous0Daria Aleshkina1Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 277 21 Libechov, Czech RepublicInstitute of Animal Physiology and Genetics, Czech Academy of Sciences, 277 21 Libechov, Czech RepublicCells are equipped with a diverse network of signaling and regulatory proteins that function as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell division. A key regulator of cell division is polo-like kinase 1 (PLK1), a member of the serine/threonine kinase family that plays an important role in regulating the mitotic and meiotic cell cycle. The phosphorylation of specific substrates mediated by PLK1 controls nuclear envelope breakdown (NEBD), centrosome maturation, proper spindle assembly, chromosome segregation, and cytokinesis. In mammalian oogenesis, PLK1 is essential for resuming meiosis before ovulation and for establishing the meiotic spindle. Among other potential roles, PLK1 regulates the localized translation of spindle-enriched mRNAs by phosphorylating and thereby inhibiting the translational repressor 4E-BP1, a downstream target of the mTOR (mammalian target of rapamycin) pathway. In this review, we summarize the functions of PLK1 in mitosis, meiosis, and cytokinesis and focus on the role of PLK1 in regulating mRNA translation. However, knowledge of the role of PLK1 in the regulation of meiosis remains limited.https://www.mdpi.com/2073-4409/12/1/187polo-like kinase 1PLK1mitosismeiosisspindleoocytes |
| spellingShingle | Jaroslav Kalous Daria Aleshkina Multiple Roles of PLK1 in Mitosis and Meiosis Cells polo-like kinase 1 PLK1 mitosis meiosis spindle oocytes |
| title | Multiple Roles of PLK1 in Mitosis and Meiosis |
| title_full | Multiple Roles of PLK1 in Mitosis and Meiosis |
| title_fullStr | Multiple Roles of PLK1 in Mitosis and Meiosis |
| title_full_unstemmed | Multiple Roles of PLK1 in Mitosis and Meiosis |
| title_short | Multiple Roles of PLK1 in Mitosis and Meiosis |
| title_sort | multiple roles of plk1 in mitosis and meiosis |
| topic | polo-like kinase 1 PLK1 mitosis meiosis spindle oocytes |
| url | https://www.mdpi.com/2073-4409/12/1/187 |
| work_keys_str_mv | AT jaroslavkalous multiplerolesofplk1inmitosisandmeiosis AT dariaaleshkina multiplerolesofplk1inmitosisandmeiosis |