CXCR6+ and NKG2C+ Natural Killer Cells Are Distinct With Unique Phenotypic and Functional Attributes Following Bone Marrow Transplantation

CXCR6+ and NKG2C+ Natural Killer Cells Are Distinct With Unique Phenotypic and Functional Attributes Following Bone Marrow Transplantation

Reactivation of human cytomegalovirus (HCMV) is a life-threatening complication in transplant patients. Natural Killer (NK) cells are the first lymphocyte lineage to reconstitute following an allogeneic hematopoietic stem cell transplant (HSCT). Amongst them, NK cell Group 2 isoform C/Killer cell le...

Full description

Bibliographic Details
Main Authors:	Kevin Aviles-Padilla, Laura S. Angelo, Dwight Fan, Silke Paust
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Immunology
Subjects:	natural killer cell human cytomegalovirus CXCR6 NKG2C bone marrow transplantation hematopoietic stem cell transplantation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.886835/full

Similar Items

Dynamic Natural Killer Cell and T Cell Responses to Influenza Infection
by: Kayla Frank, et al.
Published: (2020-08-01)

Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy
by: Cristina Zalfa, et al.
Published: (2021-05-01)

Phenotypic and Functional Plasticity of CXCR6+ Peripheral Blood NK Cells
by: Laura S. Angelo, et al.
Published: (2022-01-01)

Improvement of NK Cell Cytotoxicity in Reconstituting NK Cells after Allogeneic Stem Cell Transplantation by Blocking NKG2A Checkpoint
by: Mohammed Taha, et al.
Published: (2023-10-01)

Editorial: Emerging Concepts on the NKG2D Receptor-Ligand Axis in Health and Diseases
by: Nadia Guerra, et al.
Published: (2020-04-01)

Donor killer immunoglobulin-like receptor genes and reactivation of cytomegalovirus after HLA-matched hematopoietic stem-cell transplantation: HLA-C allotype is an essential cofactor
by: Carolyn E. Behrendt, et al.
Published: (2013-02-01)

A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys
by: Xiao Fang, et al.
Published: (2021-01-01)

Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes
by: Marcel Costa-García, et al.
Published: (2019-04-01)

Deletion of the Natural Killer Cell Receptor NKG2C Encoding KLR2C Gene and Kidney Transplant Outcome
by: Hannes Vietzen, et al.
Published: (2022-03-01)

Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System
by: Aldi Pupuleku, et al.
Published: (2017-10-01)

Endothelial cells express NKG2D ligands and desensitize antitumor NK responses
by: Thornton W Thompson, et al.
Published: (2017-12-01)

Cytomegalovirus infection in transplant recipients
by: Luiz Sergio Azevedo, et al.
Published: (2015-07-01)

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
by: Luis Romero-Martín, et al.
Published: (2022-11-01)

Economic analysis of allogeneic hematopoietic stem cell transplantation in the Bone Marrow Transplant Center of Tunisia
by: Leila Achour, et al.
Published: (2023-12-01)

CXCL12/SDF-1 and CXCR4
by: Takashi eNagasawa
Published: (2015-06-01)

Impact of NKG2D Signaling on Natural Killer and T‐Cell Function in Cerebral Ischemia
by: Christina David, et al.
Published: (2023-06-01)

Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV)
by: Samantha Barnes, et al.
Published: (2020-11-01)

Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia
by: Hannes Schmid, et al.
Published: (2018-08-01)

Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery
by: Michael M. B. Green, et al.
Published: (2016-08-01)

Antigens of Mycobacterium tuberculosis Stimulate CXCR6+ Natural Killer Cells
by: José Alberto Choreño-Parra, et al.
Published: (2020-09-01)

Adaptive Features of Natural Killer Cells in Multiple Sclerosis
by: Antía Moreira, et al.
Published: (2019-10-01)

Late Development of FcεRγneg Adaptive Natural Killer Cells Upon Human Cytomegalovirus Reactivation in Umbilical Cord Blood Transplantation Recipients
by: Letizia Muccio, et al.
Published: (2018-05-01)

Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells
by: Daniel E Morales-Mantilla, et al.
Published: (2022-02-01)

Descarga de HSV-1, HSV-2, CMV y EBV en la saliva de receptores de trasplante de precursores hematopoyéticos de la Fundación HOMI - Hospital de la Misericordia, Bogotá, D. C.
by: Sonia P. Bohórquez, et al.
Published: (2016-08-01)

Co-infection of Cytomegalovirus and Epstein-Barr Virus Diminishes the Frequency of CD56dimNKG2A+KIR− NK Cells and Contributes to Suboptimal Control of EBV in Immunosuppressed Children With Post-transplant Lymphoproliferative Disorder
by: Janice K. P. Lam, et al.
Published: (2020-06-01)

Highly specific functional equivalence of XN-HPC for optimum CD34+ cell count in harvested allogeneic bone marrow stem cell products
by: Aisha Jamal, et al.
Published: (2022-12-01)

NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
by: Jagoda Siemaszko, et al.
Published: (2021-06-01)

Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients
by: Sergi Pascual-Guardia, et al.
Published: (2020-03-01)

Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response
by: Stipan eJonjic
Published: (2011-12-01)

BAFF induces CXCR5 expression during B cell differentiation in bone marrow
by: Hajime Koizumi, et al.
Published: (2023-07-01)

γδ T Cells May Aggravate Acute Graft-Versus-Host Disease Through CXCR4 Signaling After Allogeneic Hematopoietic Transplantation
by: Ning Wu, et al.
Published: (2021-07-01)

Expression and Clinical Significance of CD8+Natural Killer T Cell Stimulatory Receptor NKG2D in Peripheral Blood of Lung Cancer Patients
by: Ni CHENG, et al.
Published: (2010-10-01)

Natural Killer Cells Are Key Host Immune Effector Cells Affecting Survival in Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation
by: Luis F. Porrata
Published: (2022-11-01)

Persistence of KIRneg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation
by: Clara Di Vito, et al.
Published: (2024-01-01)

Intrathecal cytomegalovirus immunoglobulin for CMV encephalitis post allogeneic stem cell transplantation
by: Ian Pang, et al.
Published: (2022-01-01)

The association of conditioning regimen with cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation
by: Masoud Mardani, et al.
Published: (2020-12-01)

In Vivo Emergence of UL56 C325Y Cytomegalovirus Resistance to Letermovir in a Patient with Acute Myeloid Leukemia after Hematopoietic Cell Transplantation
by: Jochen J Frietsch, et al.
Published: (2019-01-01)

Difference in the Cytomegalovirus-related Clinical Laboratory Findings Between Patients With Bone Marrow and Kidney Transplantations
by: Misagh Rajabinejad, et al.
Published: (2021-08-01)

Ovarian Hormones Regulate the Production of Adipocytes From Bone Marrow-Derived Cells
by: Kathleen M. Gavin, et al.
Published: (2018-05-01)

The Paradoxical Role of NKG2D in Cancer Immunity
by: Sam Sheppard, et al.
Published: (2018-08-01)