Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablation
Background: Blood types are classified based on the specific antigenic characteristics they possess. Despite documented associations between antigens and inflammation, a scarcity of data exists concerning the impact of antigens on atrial fibrillation (AF). Methods: OSHOH-rhythm study is a multi-cent...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602224000272 |
| _version_ | 1827304258997846016 |
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| author | Michitaka Amioka Hiroki Kinoshita Akinori Sairaku Tomoki Shokawa Yukiko Nakano |
| author_facet | Michitaka Amioka Hiroki Kinoshita Akinori Sairaku Tomoki Shokawa Yukiko Nakano |
| author_sort | Michitaka Amioka |
| collection | DOAJ |
| description | Background: Blood types are classified based on the specific antigenic characteristics they possess. Despite documented associations between antigens and inflammation, a scarcity of data exists concerning the impact of antigens on atrial fibrillation (AF). Methods: OSHOH-rhythm study is a multi-center, prospective observational study of 601 patients who underwent catheter ablation for AF. We examined the correlation between blood type groups and both the incidence and recurrence of AF. Additionally, we analyzed the recurrence of AF across antigenic profiles. Results: The frequencies of individual blood types were 239 (39.8 %), 190 (31.6 %), 122 (20.3 %), and 50 (8.3 %) for A, O, B, and AB, respectively, aligning closely with the prevalent blood type distribution among the Japanese populace. During follow-up period (18.8 months, median), AF recurrence occurred in 96 patients (22.4 %) lacking the B antigen (A and O), and 26 patients (15.1 %) possessing B antigen (B and AB), respectively (Log-rank test: P = 0.034). A multivariate analysis demonstrated that blood types lacking the B antigen (hazard ratio [HR], 1.55; 95 % CI, 1.01 to 2.42; P = 0.037), hypertension (HR, 1.51; 95 % CI, 1.05 to 2.17; P = 0.026) and non-paroxysmal AF (HR, 1.70; 95 % CI, 1.17 to 2.47; P = 0.005) were independently associated with the recurrence of AF. Conclusions: This study elucidates that, despite the absence of direct correlation between blood types and the occurrence of AF, blood types devoid of the B antigen exhibit an enhanced predisposition to AF recurrence. Nonetheless, the intricate mechanism linking blood type to recurrence remains elusive, warranting further comprehensive foundational research on blood types. |
| first_indexed | 2024-04-24T17:26:47Z |
| format | Article |
| id | doaj.art-3de93a2068584f7f8245f6c363b29e7a |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-24T17:26:47Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-3de93a2068584f7f8245f6c363b29e7a2024-03-28T06:39:00ZengElsevierAmerican Heart Journal Plus2666-60222024-04-0140100384Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablationMichitaka Amioka0Hiroki Kinoshita1Akinori Sairaku2Tomoki Shokawa3Yukiko Nakano4Deparment of Cardiovascular Medicine, Hiroshima General Hospital, Hiroshima, Japan; Corresponding author at: Department of Cardiovascular Medicine, Hiroshima General Hospital, 1-3-3, Jigozen, Hatsukaichi-shi, Hiroshima 738-8503, Japan.Deparment of Cardiovascular Medicine, Onomichi General Hospital, Hiroshima, JapanDeparment of Cardiovascular Medicine, NHO Higashihiroshima Medical Center, Hiroshima, JapanDeparment of Cardiovascular Medicine, Hiroshima General Hospital, Hiroshima, JapanDeparment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, JapanBackground: Blood types are classified based on the specific antigenic characteristics they possess. Despite documented associations between antigens and inflammation, a scarcity of data exists concerning the impact of antigens on atrial fibrillation (AF). Methods: OSHOH-rhythm study is a multi-center, prospective observational study of 601 patients who underwent catheter ablation for AF. We examined the correlation between blood type groups and both the incidence and recurrence of AF. Additionally, we analyzed the recurrence of AF across antigenic profiles. Results: The frequencies of individual blood types were 239 (39.8 %), 190 (31.6 %), 122 (20.3 %), and 50 (8.3 %) for A, O, B, and AB, respectively, aligning closely with the prevalent blood type distribution among the Japanese populace. During follow-up period (18.8 months, median), AF recurrence occurred in 96 patients (22.4 %) lacking the B antigen (A and O), and 26 patients (15.1 %) possessing B antigen (B and AB), respectively (Log-rank test: P = 0.034). A multivariate analysis demonstrated that blood types lacking the B antigen (hazard ratio [HR], 1.55; 95 % CI, 1.01 to 2.42; P = 0.037), hypertension (HR, 1.51; 95 % CI, 1.05 to 2.17; P = 0.026) and non-paroxysmal AF (HR, 1.70; 95 % CI, 1.17 to 2.47; P = 0.005) were independently associated with the recurrence of AF. Conclusions: This study elucidates that, despite the absence of direct correlation between blood types and the occurrence of AF, blood types devoid of the B antigen exhibit an enhanced predisposition to AF recurrence. Nonetheless, the intricate mechanism linking blood type to recurrence remains elusive, warranting further comprehensive foundational research on blood types.http://www.sciencedirect.com/science/article/pii/S2666602224000272ABO blood typesB antigenAtrial fibrillation |
| spellingShingle | Michitaka Amioka Hiroki Kinoshita Akinori Sairaku Tomoki Shokawa Yukiko Nakano Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablation American Heart Journal Plus ABO blood types B antigen Atrial fibrillation |
| title | Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablation |
| title_full | Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablation |
| title_fullStr | Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablation |
| title_full_unstemmed | Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablation |
| title_short | Impact of ABO blood type on the risk of atrial fibrillation recurrence after catheter ablation |
| title_sort | impact of abo blood type on the risk of atrial fibrillation recurrence after catheter ablation |
| topic | ABO blood types B antigen Atrial fibrillation |
| url | http://www.sciencedirect.com/science/article/pii/S2666602224000272 |
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