Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

Abstract The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis. Two COX isoforms (COX1/2) share 60% sequence structure, yet their functions...

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Bibliographic Details
Main Authors: Christopher J. Esh, Bryna C. R. Chrismas, Alexis R. Mauger, Lee Taylor
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Pharmacology Research & Perspectives
Subjects:
acetaminophen
arachidonic acid
cyclooxygenase
mechanism of action
Online Access:https://doi.org/10.1002/prp2.835

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