FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSIS
OBJECTIVE: To determine the frequency of 25-hydroxy vitamin-D deficiency in Patients with multiple sclerosis (MS). METHODS: This cross-sectional study was conducted at Civil Hospital Karachi, Pakistan from January to December 2019. One hundred and sixty five diagnosed cases of MS of either gender...
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| Format: | Article |
| Language: | English |
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Khyber Medical University
2022-03-01
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| Series: | Khyber Medical University Journal |
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| Online Access: | https://www.kmuj.kmu.edu.pk/article/view/22039 |
| _version_ | 1797807233077084160 |
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| author | Mehwish Arif Butt Asma Arman Tahir Ansari |
| author_facet | Mehwish Arif Butt Asma Arman Tahir Ansari |
| author_sort | Mehwish Arif Butt |
| collection | DOAJ |
| description | OBJECTIVE: To determine the frequency of 25-hydroxy vitamin-D deficiency in Patients with multiple sclerosis (MS).
METHODS: This cross-sectional study was conducted at Civil Hospital Karachi, Pakistan from January to December 2019. One hundred and sixty five diagnosed cases of MS of either gender, aging 20-55 years, not taking vitamin-D supplements, steroids and could go outside in the sun were selected through non-probability consecutive sampling technique. Patients having history of rickets, parathyroid disease, chronic liver or renal diseases were excluded. Blood sample was taken to measure 25-hydroxyl vitamin D3 levels. A level of <20 ng/ml was considered as vitamin-D deficient. Logistic regression analysis was used to identify determinants.
RESULTS: Out of 165 MS patients, 106 (64.24%) were females, 66 (40%) had income between PKR 10000-25000, 51 (30.9%) were illiterate and 12 (7.3%) had graduate level education. Majority (n=101; 61.21%) had relapsing-remitting MS. Mean age of enrolled participants was 32.92±8.19 years and mean duration of MS was 2.17±0.84 years. Ninety-nine (60%) patients had history of adequate sun exposure. Vitamin-D deficiency in MS patients was 55 (33.3%). Female patients with MS had 2.9 times more likely to be vitamin-D deficient compared to male patients (95% CI: 1.3-6.5). Vitamin-D deficiency In MS patients having no or primary level education patients was recorded in 38 (69.1%) patients as compared to 17 (31.9%) case having secondary or higher education (p-value=0.046).
CONCLUSION: Vitamin-D deficiency is common in MS patients. Female and less educated MS patients are at a higher risk of being vitamin-D deficient. |
| first_indexed | 2024-03-13T06:19:29Z |
| format | Article |
| id | doaj.art-3deb4da7682e4d41b6d34059036b3ad4 |
| institution | Directory Open Access Journal |
| issn | 2305-2643 2305-2651 |
| language | English |
| last_indexed | 2024-03-13T06:19:29Z |
| publishDate | 2022-03-01 |
| publisher | Khyber Medical University |
| record_format | Article |
| series | Khyber Medical University Journal |
| spelling | doaj.art-3deb4da7682e4d41b6d34059036b3ad42023-06-10T03:23:21ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512022-03-0114142610.35845/kmuj.2022.220391692FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSISMehwish Arif Butt0Asma Arman1Tahir Ansari2Department of Neurology, Dr. Ruth K. M Pfau Civil Hospital, Karachi, Pakistan and currently working in Department of Neurology, Jinnah Medical & Dental College Hospital, Karachi, PakistanDepartment of Neurology, Fazaia Ruth Pfau Medical College, Karachi, PakistanDepartment of Medicine, Fazaia Ruth Pfau Medical College, Karachi, PakistanOBJECTIVE: To determine the frequency of 25-hydroxy vitamin-D deficiency in Patients with multiple sclerosis (MS). METHODS: This cross-sectional study was conducted at Civil Hospital Karachi, Pakistan from January to December 2019. One hundred and sixty five diagnosed cases of MS of either gender, aging 20-55 years, not taking vitamin-D supplements, steroids and could go outside in the sun were selected through non-probability consecutive sampling technique. Patients having history of rickets, parathyroid disease, chronic liver or renal diseases were excluded. Blood sample was taken to measure 25-hydroxyl vitamin D3 levels. A level of <20 ng/ml was considered as vitamin-D deficient. Logistic regression analysis was used to identify determinants. RESULTS: Out of 165 MS patients, 106 (64.24%) were females, 66 (40%) had income between PKR 10000-25000, 51 (30.9%) were illiterate and 12 (7.3%) had graduate level education. Majority (n=101; 61.21%) had relapsing-remitting MS. Mean age of enrolled participants was 32.92±8.19 years and mean duration of MS was 2.17±0.84 years. Ninety-nine (60%) patients had history of adequate sun exposure. Vitamin-D deficiency in MS patients was 55 (33.3%). Female patients with MS had 2.9 times more likely to be vitamin-D deficient compared to male patients (95% CI: 1.3-6.5). Vitamin-D deficiency In MS patients having no or primary level education patients was recorded in 38 (69.1%) patients as compared to 17 (31.9%) case having secondary or higher education (p-value=0.046). CONCLUSION: Vitamin-D deficiency is common in MS patients. Female and less educated MS patients are at a higher risk of being vitamin-D deficient.https://www.kmuj.kmu.edu.pk/article/view/22039multiple sclerosisvitamin driskvitamin d deficiencyeducational statussocioeconomic factorsfemalemale |
| spellingShingle | Mehwish Arif Butt Asma Arman Tahir Ansari FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSIS Khyber Medical University Journal multiple sclerosis vitamin d risk vitamin d deficiency educational status socioeconomic factors female male |
| title | FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSIS |
| title_full | FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSIS |
| title_fullStr | FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSIS |
| title_full_unstemmed | FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSIS |
| title_short | FREQUENCY OF 25-HYDROXY VITAMIN D DEFICIENCY IN PATIENTS WITH MULTIPLE SCLEROSIS |
| title_sort | frequency of 25 hydroxy vitamin d deficiency in patients with multiple sclerosis |
| topic | multiple sclerosis vitamin d risk vitamin d deficiency educational status socioeconomic factors female male |
| url | https://www.kmuj.kmu.edu.pk/article/view/22039 |
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