Antitumor Effects of Selenium
Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11844 |
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| author | Seung Jo Kim Min Chul Choi Jong Min Park An Sik Chung |
| author_facet | Seung Jo Kim Min Chul Choi Jong Min Park An Sik Chung |
| author_sort | Seung Jo Kim |
| collection | DOAJ |
| description | Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and reduction mechanisms of selenium metabolites. Hydrogen selenide from selenite, and methylselenol (MSeH) from Se-methylselenocyteine (MSeC) and methylseleninicacid (MSeA) are the most reactive metabolites produced reactive oxygen species (ROS); furthermore, these metabolites may involve in oxidizing sulfhydryl groups, including glutathione. Selenite also reacted with glutathione and produces hydrogen selenide via selenodiglutathione (SeDG), which induces cytotoxicity as cell apoptosis, ROS production, DNA damage, and adenosine-methionine methylation in the cellular nucleus. However, a more pronounced effect was shown in the subsequent treatment of sodium selenite with chemotherapy and radiation therapy. High doses of sodium selenite were effective to increase radiation therapy and chemotherapy, and further to reduce radiation side effects and drug resistance. In our study, advanced cancer patients can tolerate until 5000 μg of sodium selenite in combination with radiation and chemotherapy since the half-life of sodium selenite may be relatively short, and, further, selenium may accumulates more in cancer cells than that of normal cells, which may be toxic to the cancer cells. Further clinical studies of high amount sodium selenite are required to treat advanced cancer patients. |
| first_indexed | 2024-03-10T06:00:31Z |
| format | Article |
| id | doaj.art-3deb5e03f9634b0f82b74818cfef5990 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:00:31Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3deb5e03f9634b0f82b74818cfef59902023-11-22T20:58:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211184410.3390/ijms222111844Antitumor Effects of SeleniumSeung Jo Kim0Min Chul Choi1Jong Min Park2An Sik Chung3Sangkyungwon Integrate Medical Caner Hospital, Yeoju 12616, Gyeonggido, KoreaComprehensive Gynecological Cancer Center, CHA Bundang Medical Center, Seongnam 13497, Gyeonggido, KoreaOriental Medicine, Daejeon University, Daejeon 34520, KoreaDepartment of Biological Sciences, Korea Advanced Institute of Science and technology, Daejeon 34141, KoreaFunctions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and reduction mechanisms of selenium metabolites. Hydrogen selenide from selenite, and methylselenol (MSeH) from Se-methylselenocyteine (MSeC) and methylseleninicacid (MSeA) are the most reactive metabolites produced reactive oxygen species (ROS); furthermore, these metabolites may involve in oxidizing sulfhydryl groups, including glutathione. Selenite also reacted with glutathione and produces hydrogen selenide via selenodiglutathione (SeDG), which induces cytotoxicity as cell apoptosis, ROS production, DNA damage, and adenosine-methionine methylation in the cellular nucleus. However, a more pronounced effect was shown in the subsequent treatment of sodium selenite with chemotherapy and radiation therapy. High doses of sodium selenite were effective to increase radiation therapy and chemotherapy, and further to reduce radiation side effects and drug resistance. In our study, advanced cancer patients can tolerate until 5000 μg of sodium selenite in combination with radiation and chemotherapy since the half-life of sodium selenite may be relatively short, and, further, selenium may accumulates more in cancer cells than that of normal cells, which may be toxic to the cancer cells. Further clinical studies of high amount sodium selenite are required to treat advanced cancer patients.https://www.mdpi.com/1422-0067/22/21/11844selenium compoundsROSapoptosismetastasistreatment of advanced cancer patients |
| spellingShingle | Seung Jo Kim Min Chul Choi Jong Min Park An Sik Chung Antitumor Effects of Selenium International Journal of Molecular Sciences selenium compounds ROS apoptosis metastasis treatment of advanced cancer patients |
| title | Antitumor Effects of Selenium |
| title_full | Antitumor Effects of Selenium |
| title_fullStr | Antitumor Effects of Selenium |
| title_full_unstemmed | Antitumor Effects of Selenium |
| title_short | Antitumor Effects of Selenium |
| title_sort | antitumor effects of selenium |
| topic | selenium compounds ROS apoptosis metastasis treatment of advanced cancer patients |
| url | https://www.mdpi.com/1422-0067/22/21/11844 |
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