The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory
Introduction: Patients with epilepsy can have impaired cognitive abilities. Many factors contribute to this impairment, including the adverse effects of antiepileptic drugs like Gabapentin (GBP). Apart from anti-epilectic action, Gabapentin is used to relieve ethanol withdrawal syndrome. Because bot...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2011-09-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-2-20&slc_lang=en&sid=1 |
| _version_ | 1797280569907740672 |
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| author | Fahimeh Yeganeh Farnaz Nikbakht Homa Rasouli |
| author_facet | Fahimeh Yeganeh Farnaz Nikbakht Homa Rasouli |
| author_sort | Fahimeh Yeganeh |
| collection | DOAJ |
| description | Introduction: Patients with epilepsy can have impaired cognitive abilities. Many factors contribute to this impairment, including the adverse effects of antiepileptic drugs like Gabapentin (GBP). Apart from anti-epilectic action, Gabapentin is used to relieve ethanol withdrawal syndrome. Because both GBP and ethanol act on GABA ergic system, the purpose of this study was to evaluate their effect and interaction on spatial learning and memory. Material and Methods: Male Sprague-Dawley rats were trained in the Morris water maze for 5 consecutive days. On the sixth day, a probe test was performed to assess the retention phase or spatial rats’ memory ability. Ethanol (1.5 g/kg i.p.) and GBP (30 mg/kg i.p.) was administered each day 30 and 40 minutes before testing respectively. Results: Acute ethanol administration selectively impaired spatial memory (p<0.05), yet it failed to impair the acquisition phase (learning). Contradictorily GBP selectively impaired learning on second and forth days. Conclusion: These findings demonstrate that GBP and acute ethanol impair different phases of learning probably by modifying different neuronal pathways in cognitive areas of the brain. |
| first_indexed | 2024-03-07T16:43:08Z |
| format | Article |
| id | doaj.art-3dec892d018e4294a80af8bbf50888a5 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:43:08Z |
| publishDate | 2011-09-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-3dec892d018e4294a80af8bbf50888a52024-03-03T07:15:31ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422011-09-01224447The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and MemoryFahimeh Yeganeh0Farnaz Nikbakht1Homa Rasouli2 Introduction: Patients with epilepsy can have impaired cognitive abilities. Many factors contribute to this impairment, including the adverse effects of antiepileptic drugs like Gabapentin (GBP). Apart from anti-epilectic action, Gabapentin is used to relieve ethanol withdrawal syndrome. Because both GBP and ethanol act on GABA ergic system, the purpose of this study was to evaluate their effect and interaction on spatial learning and memory. Material and Methods: Male Sprague-Dawley rats were trained in the Morris water maze for 5 consecutive days. On the sixth day, a probe test was performed to assess the retention phase or spatial rats’ memory ability. Ethanol (1.5 g/kg i.p.) and GBP (30 mg/kg i.p.) was administered each day 30 and 40 minutes before testing respectively. Results: Acute ethanol administration selectively impaired spatial memory (p<0.05), yet it failed to impair the acquisition phase (learning). Contradictorily GBP selectively impaired learning on second and forth days. Conclusion: These findings demonstrate that GBP and acute ethanol impair different phases of learning probably by modifying different neuronal pathways in cognitive areas of the brain.http://bcn.iums.ac.ir/browse.php?a_code=A-10-2-20&slc_lang=en&sid=1Spatial MemoryLeraningAcute EthanolGabapentin |
| spellingShingle | Fahimeh Yeganeh Farnaz Nikbakht Homa Rasouli The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory Basic and Clinical Neuroscience Spatial Memory Leraning Acute Ethanol Gabapentin |
| title | The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory |
| title_full | The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory |
| title_fullStr | The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory |
| title_full_unstemmed | The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory |
| title_short | The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory |
| title_sort | effect of acute ethanol and gabapentin administration on spatial learning and memory |
| topic | Spatial Memory Leraning Acute Ethanol Gabapentin |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-2-20&slc_lang=en&sid=1 |
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