Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation
Background: Elderly adults with atrial fibrillation (AF) are at increased risk of frailty and thromboembolic complications. However, studies on the prevalence of frailty in AF patients and data on the relationship between frailty and the use of anticoagulants are limited. Methods: We conducted a c...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2020-01-01
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| Series: | Cardiovascular Innovations and Applications |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2019.0562 |
| _version_ | 1827304712562540544 |
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| author | Jiapeng Liu Xin Du Mengmeng Li Zhaoxu Jia Shangxin Lu Sanshuai Chang Ribo Tang Rong Bai Jianzeng Dong Gregory Y. H. Lip Changsheng Ma |
| author_facet | Jiapeng Liu Xin Du Mengmeng Li Zhaoxu Jia Shangxin Lu Sanshuai Chang Ribo Tang Rong Bai Jianzeng Dong Gregory Y. H. Lip Changsheng Ma |
| author_sort | Jiapeng Liu |
| collection | DOAJ |
| description | Background: Elderly adults with atrial fibrillation (AF) are at increased risk of frailty and thromboembolic complications. However, studies on the prevalence of frailty in AF patients and data on the relationship between frailty and the use of anticoagulants are limited. Methods: We conducted a cross-sectional study involving 500 participants. Patients aged 65 years or older were consecutively selected from the Chinese Atrial Fibrillation Registry study. The patient’s frailty status was assessed with use of the Canadian Study of Health and Aging Clinical Frailty Scale. We assessed the prevalence of and factors associated with frailty, and how frailty affects anticoagulant therapy. Results: In 500 elderly adults with AF (age 75.2±6.7 years; 51.6% female), 201 patients (40.2%) were frail. The prevalence of frailty was higher in females (P=0.002) and increased with age and CHA 2 DS 2 -VASc score (P for trend less than 0.001 for both). The factors associated with frailty were a history of heart failure (odds ratio [OR] 2.40, 95% confidence interval [CI] 1.39–4.14), female sex (OR 2.09, 95% CI 1.27–3.43), and advanced age (OR 1.13, 95% CI 1.09–1.17). Frail patients were significantly less likely to have ever been prescribed anticoagulants compared with nonfrail patients (81.7 vs. 54.9%, P<0.001). Conclusions: Frailty is prevalent in elderly adults with AF, especially in females, those of advanced age, and those with heart failure. Frailty status has a significant impact on prescription of anticoagulants for high-risk AF patients. |
| first_indexed | 2024-03-13T02:49:16Z |
| format | Article |
| id | doaj.art-3dec9893335441ddbbb8222bf2035402 |
| institution | Directory Open Access Journal |
| issn | 2009-8618 2009-8782 |
| language | English |
| last_indexed | 2024-04-24T17:43:44Z |
| publishDate | 2020-01-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Cardiovascular Innovations and Applications |
| spelling | doaj.art-3dec9893335441ddbbb8222bf20354022024-03-27T16:00:12ZengCompuscript LtdCardiovascular Innovations and Applications2009-86182009-87822020-01-014315316110.15212/CVIA.2019.0562Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial FibrillationJiapeng LiuXin DuMengmeng LiZhaoxu JiaShangxin LuSanshuai ChangRibo TangRong BaiJianzeng DongGregory Y. H. LipChangsheng MaBackground: Elderly adults with atrial fibrillation (AF) are at increased risk of frailty and thromboembolic complications. However, studies on the prevalence of frailty in AF patients and data on the relationship between frailty and the use of anticoagulants are limited. Methods: We conducted a cross-sectional study involving 500 participants. Patients aged 65 years or older were consecutively selected from the Chinese Atrial Fibrillation Registry study. The patient’s frailty status was assessed with use of the Canadian Study of Health and Aging Clinical Frailty Scale. We assessed the prevalence of and factors associated with frailty, and how frailty affects anticoagulant therapy. Results: In 500 elderly adults with AF (age 75.2±6.7 years; 51.6% female), 201 patients (40.2%) were frail. The prevalence of frailty was higher in females (P=0.002) and increased with age and CHA 2 DS 2 -VASc score (P for trend less than 0.001 for both). The factors associated with frailty were a history of heart failure (odds ratio [OR] 2.40, 95% confidence interval [CI] 1.39–4.14), female sex (OR 2.09, 95% CI 1.27–3.43), and advanced age (OR 1.13, 95% CI 1.09–1.17). Frail patients were significantly less likely to have ever been prescribed anticoagulants compared with nonfrail patients (81.7 vs. 54.9%, P<0.001). Conclusions: Frailty is prevalent in elderly adults with AF, especially in females, those of advanced age, and those with heart failure. Frailty status has a significant impact on prescription of anticoagulants for high-risk AF patients.https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2019.0562 |
| spellingShingle | Jiapeng Liu Xin Du Mengmeng Li Zhaoxu Jia Shangxin Lu Sanshuai Chang Ribo Tang Rong Bai Jianzeng Dong Gregory Y. H. Lip Changsheng Ma Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation Cardiovascular Innovations and Applications |
| title | Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation |
| title_full | Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation |
| title_fullStr | Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation |
| title_full_unstemmed | Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation |
| title_short | Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation |
| title_sort | frailty and anticoagulant therapy in patients aged 65 years or older with atrial fibrillation |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2019.0562 |
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