Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection
Abstract Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a permissive non-neuronal cell culture, HSV-1 concludes the entire life cycle in app...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13578-020-00430-2 |
| _version_ | 1819011171079946240 |
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| author | Qiaojuan Zhang Miguel Martin-Caraballo Shaochung V. Hsia |
| author_facet | Qiaojuan Zhang Miguel Martin-Caraballo Shaochung V. Hsia |
| author_sort | Qiaojuan Zhang |
| collection | DOAJ |
| description | Abstract Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a permissive non-neuronal cell culture, HSV-1 concludes the entire life cycle in approximately 18–20 h, encoding approximately 90 unique transcriptional units. In latency, the robust viral gene expression is suppressed in neurons by a group of noncoding RNA. Historically the lesions caused by the virus can date back to centuries ago. As a neurotropic pathogen, HSV-1 is associated with painful oral lesions, severe keratitis and lethal encephalitis. Transmission of pain signals is dependent on the generation and propagation of action potential in sensory neurons. T-type Ca2+ channels serve as a preamplifier of action potential generation. Voltage-gated Na+ channels are the main components for action potential production. This review summarizes not only the voltage-gated ion channels in neuropathic disorders but also provides the new insights into HSV-1 induced pain. |
| first_indexed | 2024-12-21T01:23:55Z |
| format | Article |
| id | doaj.art-3ded90785c0444579c0da3776e1e78f4 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-21T01:23:55Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-3ded90785c0444579c0da3776e1e78f42022-12-21T19:20:34ZengBMCCell & Bioscience2045-37012020-05-0110111510.1186/s13578-020-00430-2Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infectionQiaojuan Zhang0Miguel Martin-Caraballo1Shaochung V. Hsia2Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern ShoreDepartment of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern ShoreDepartment of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern ShoreAbstract Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a permissive non-neuronal cell culture, HSV-1 concludes the entire life cycle in approximately 18–20 h, encoding approximately 90 unique transcriptional units. In latency, the robust viral gene expression is suppressed in neurons by a group of noncoding RNA. Historically the lesions caused by the virus can date back to centuries ago. As a neurotropic pathogen, HSV-1 is associated with painful oral lesions, severe keratitis and lethal encephalitis. Transmission of pain signals is dependent on the generation and propagation of action potential in sensory neurons. T-type Ca2+ channels serve as a preamplifier of action potential generation. Voltage-gated Na+ channels are the main components for action potential production. This review summarizes not only the voltage-gated ion channels in neuropathic disorders but also provides the new insights into HSV-1 induced pain.http://link.springer.com/article/10.1186/s13578-020-00430-2HerpesvirusHSV-1LatencyReactivationVoltage-gated sodium channelT-type calcium channels |
| spellingShingle | Qiaojuan Zhang Miguel Martin-Caraballo Shaochung V. Hsia Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection Cell & Bioscience Herpesvirus HSV-1 Latency Reactivation Voltage-gated sodium channel T-type calcium channels |
| title | Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection |
| title_full | Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection |
| title_fullStr | Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection |
| title_full_unstemmed | Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection |
| title_short | Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection |
| title_sort | pathophysiological roles and therapeutic potential of voltage gated ion channels vgics in pain associated with herpesvirus infection |
| topic | Herpesvirus HSV-1 Latency Reactivation Voltage-gated sodium channel T-type calcium channels |
| url | http://link.springer.com/article/10.1186/s13578-020-00430-2 |
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