High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study
Abstract Background Patients with acute myocardial infarction (AMI) often accompanied by admission hyperglycemia, which usually predicts a poor clinical outcomes for non-diabetes mellitus. Appropriate cut-point to identify high risk individuals in these patients remains controversial. Methods One th...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-019-1140-1 |
| _version_ | 1811270545010851840 |
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| author | Xiao Song Ding Shan Shan Wu Hui Chen Xue Qiao Zhao Hong Wei Li |
| author_facet | Xiao Song Ding Shan Shan Wu Hui Chen Xue Qiao Zhao Hong Wei Li |
| author_sort | Xiao Song Ding |
| collection | DOAJ |
| description | Abstract Background Patients with acute myocardial infarction (AMI) often accompanied by admission hyperglycemia, which usually predicts a poor clinical outcomes for non-diabetes mellitus. Appropriate cut-point to identify high risk individuals in these patients remains controversial. Methods One thousand six hundred ninety-eight non-diabetes AMI patients in this retrospective study were divided into 3 groups according to admission glucose levels (euglycemia group≤140 mg/dL, moderate hyperglycemia group 141–179 mg/dL, severe hyperglycemia group≥180 mg/dL). The primary endpoint of this study was all-cause in-hospital mortality rate. In-hospital motality related risk factors was analyzed by multivariate binary logistic regression analyses. Results All myocardial necrosis markers and Log NT-proBNP in severe hyperglycemia group were significantly higher than those in the other 2 groups. Logistic regression showed that independent predictors of the in-hospital mortality rate in non-diabetic patients with AMI were age (OR = 1.057, 95% CI 1.024–1.091, P < 0.001), logarithm of the N-terminal pro-brain natriuretic peptide (OR = 7.697, 95% CI 3.810–15.550, P < 0.001), insufficient myocardial reperfusion (OR = 7.654, 95% CI 2.109–27.779, P < 0.001), percutaneous coronary intervention (OR = 0.221, 95% CI 0.108–0.452, P < 0.001) and admission glucose (as categorical variable). Patients with moderate hyperglycemia (OR = 1.186, 95% CI 0.585–2.408, P = .636) and severe hyperglycemia (OR = 4.595, 95% CI 1.942–10.873, P = 0.001) had a higher all-cause in-hospital mortality rate compared with those with euglycemia after AMI in non-diabetic patients. Conclusions The all-cause in-hospital mortality risk increases remarkably as admission glucose levels elevated in non-diabetic patients with AMI, especially in patients with admission glucose levels ≥180 mg/dL. Severe admission hyperglycemia could be regarded as prospective high-risk marker for non-diabetic AMI patients. |
| first_indexed | 2024-04-12T22:03:51Z |
| format | Article |
| id | doaj.art-3dedbf5c0fb848348746b15433334b0f |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-12T22:03:51Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-3dedbf5c0fb848348746b15433334b0f2022-12-22T03:15:01ZengBMCBMC Cardiovascular Disorders1471-22612019-07-011911910.1186/s12872-019-1140-1High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational studyXiao Song Ding0Shan Shan Wu1Hui Chen2Xue Qiao Zhao3Hong Wei Li4Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical UniversityNational Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical UniversityClinical Atherosclerosis Research Lab, Division of Cardiology, University of WashingtonDepartment of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical UniversityAbstract Background Patients with acute myocardial infarction (AMI) often accompanied by admission hyperglycemia, which usually predicts a poor clinical outcomes for non-diabetes mellitus. Appropriate cut-point to identify high risk individuals in these patients remains controversial. Methods One thousand six hundred ninety-eight non-diabetes AMI patients in this retrospective study were divided into 3 groups according to admission glucose levels (euglycemia group≤140 mg/dL, moderate hyperglycemia group 141–179 mg/dL, severe hyperglycemia group≥180 mg/dL). The primary endpoint of this study was all-cause in-hospital mortality rate. In-hospital motality related risk factors was analyzed by multivariate binary logistic regression analyses. Results All myocardial necrosis markers and Log NT-proBNP in severe hyperglycemia group were significantly higher than those in the other 2 groups. Logistic regression showed that independent predictors of the in-hospital mortality rate in non-diabetic patients with AMI were age (OR = 1.057, 95% CI 1.024–1.091, P < 0.001), logarithm of the N-terminal pro-brain natriuretic peptide (OR = 7.697, 95% CI 3.810–15.550, P < 0.001), insufficient myocardial reperfusion (OR = 7.654, 95% CI 2.109–27.779, P < 0.001), percutaneous coronary intervention (OR = 0.221, 95% CI 0.108–0.452, P < 0.001) and admission glucose (as categorical variable). Patients with moderate hyperglycemia (OR = 1.186, 95% CI 0.585–2.408, P = .636) and severe hyperglycemia (OR = 4.595, 95% CI 1.942–10.873, P = 0.001) had a higher all-cause in-hospital mortality rate compared with those with euglycemia after AMI in non-diabetic patients. Conclusions The all-cause in-hospital mortality risk increases remarkably as admission glucose levels elevated in non-diabetic patients with AMI, especially in patients with admission glucose levels ≥180 mg/dL. Severe admission hyperglycemia could be regarded as prospective high-risk marker for non-diabetic AMI patients.http://link.springer.com/article/10.1186/s12872-019-1140-1Acute myocardial infarctionAdmission hyperglycemiaNon-diabetes mellitusIn-hospital mortality |
| spellingShingle | Xiao Song Ding Shan Shan Wu Hui Chen Xue Qiao Zhao Hong Wei Li High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study BMC Cardiovascular Disorders Acute myocardial infarction Admission hyperglycemia Non-diabetes mellitus In-hospital mortality |
| title | High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study |
| title_full | High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study |
| title_fullStr | High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study |
| title_full_unstemmed | High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study |
| title_short | High admission glucose levels predict worse short-term clinical outcome in non-diabetic patients with acute myocardial infraction: a retrospective observational study |
| title_sort | high admission glucose levels predict worse short term clinical outcome in non diabetic patients with acute myocardial infraction a retrospective observational study |
| topic | Acute myocardial infarction Admission hyperglycemia Non-diabetes mellitus In-hospital mortality |
| url | http://link.springer.com/article/10.1186/s12872-019-1140-1 |
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