Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review
<b>Background:</b> Accurate prenatal diagnosis of cleft lip and palate is essential to discuss severity prediction, perform appropriate parental counseling, and, at last, establish long-term treatment planning. The aim of this systematic review was to analyze the accuracy of various imag...
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| Format: | Article |
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MDPI AG
2024-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/2090 |
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| author | Ana Baeza-Pagador Ana Tejero-Martínez Lucas Salom-Alonso Sara Camañes-Gonzalvo Verónica García-Sanz Vanessa Paredes-Gallardo |
| author_facet | Ana Baeza-Pagador Ana Tejero-Martínez Lucas Salom-Alonso Sara Camañes-Gonzalvo Verónica García-Sanz Vanessa Paredes-Gallardo |
| author_sort | Ana Baeza-Pagador |
| collection | DOAJ |
| description | <b>Background:</b> Accurate prenatal diagnosis of cleft lip and palate is essential to discuss severity prediction, perform appropriate parental counseling, and, at last, establish long-term treatment planning. The aim of this systematic review was to analyze the accuracy of various imaging techniques for the prenatal diagnosis of cleft lip and palate, assess the pregnancy phase for orofacial clefts diagnosis, and study the different cleft types in terms of diagnostic methods, timing, and predictability. <b>Methods:</b> A search of the PubMed, EMBASE, Scopus, and Web of Science databases was conducted to identify potentially relevant studies published until January 2024. The quality of the selected articles was assessed using the Newcastle–Ottawa scale for methodological quality assessment of cohort studies and the QUADAS-2 scale for diagnostic test studies. <b>Results:</b> A total of 18 studies met the eligibility criteria and were included in the review. The findings of this review indicate that the majority of studies showed improved diagnostic accuracy when supplementary techniques, such as 3D ultrasound or magnetic resonance imaging, were added to 2D ultrasound. <b>Conclusions:</b> The implementation of magnetic resonance imaging as a standard procedure could significantly improve the precision of diagnosing cleft lip and palate. Therefore, the diagnostic technique used will play a crucial role in the accuracy of the diagnosis. |
| first_indexed | 2024-04-24T10:41:02Z |
| format | Article |
| id | doaj.art-3dedf4ae833b448ca3a83cffb6ab279f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T10:41:02Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3dedf4ae833b448ca3a83cffb6ab279f2024-04-12T13:21:31ZengMDPI AGJournal of Clinical Medicine2077-03832024-04-01137209010.3390/jcm13072090Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic ReviewAna Baeza-Pagador0Ana Tejero-Martínez1Lucas Salom-Alonso2Sara Camañes-Gonzalvo3Verónica García-Sanz4Vanessa Paredes-Gallardo5Orthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, SpainOrthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, SpainDepartment of Maxillofacial Surgery, La Fe Hospital, 46026 Valencia, SpainOrthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, SpainOrthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, SpainOrthodontics Teaching Unit, Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain<b>Background:</b> Accurate prenatal diagnosis of cleft lip and palate is essential to discuss severity prediction, perform appropriate parental counseling, and, at last, establish long-term treatment planning. The aim of this systematic review was to analyze the accuracy of various imaging techniques for the prenatal diagnosis of cleft lip and palate, assess the pregnancy phase for orofacial clefts diagnosis, and study the different cleft types in terms of diagnostic methods, timing, and predictability. <b>Methods:</b> A search of the PubMed, EMBASE, Scopus, and Web of Science databases was conducted to identify potentially relevant studies published until January 2024. The quality of the selected articles was assessed using the Newcastle–Ottawa scale for methodological quality assessment of cohort studies and the QUADAS-2 scale for diagnostic test studies. <b>Results:</b> A total of 18 studies met the eligibility criteria and were included in the review. The findings of this review indicate that the majority of studies showed improved diagnostic accuracy when supplementary techniques, such as 3D ultrasound or magnetic resonance imaging, were added to 2D ultrasound. <b>Conclusions:</b> The implementation of magnetic resonance imaging as a standard procedure could significantly improve the precision of diagnosing cleft lip and palate. Therefore, the diagnostic technique used will play a crucial role in the accuracy of the diagnosis.https://www.mdpi.com/2077-0383/13/7/2090cleft lipcleft palatefetuspregnancy2D ultrasound3D ultrasound |
| spellingShingle | Ana Baeza-Pagador Ana Tejero-Martínez Lucas Salom-Alonso Sara Camañes-Gonzalvo Verónica García-Sanz Vanessa Paredes-Gallardo Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review Journal of Clinical Medicine cleft lip cleft palate fetus pregnancy 2D ultrasound 3D ultrasound |
| title | Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review |
| title_full | Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review |
| title_fullStr | Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review |
| title_full_unstemmed | Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review |
| title_short | Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review |
| title_sort | diagnostic methods for the prenatal detection of cleft lip and palate a systematic review |
| topic | cleft lip cleft palate fetus pregnancy 2D ultrasound 3D ultrasound |
| url | https://www.mdpi.com/2077-0383/13/7/2090 |
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