Age-associated B cells in viral infection
Age-associated B cells (ABCs) are a recently identified, unique B cell population that displays both protective and pathogenic characteristics, depending on the context. A major role of ABCs is to protect from viral infection. ABCs expand during an array of viral infections and display various funct...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-03-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929649/?tool=EBI |
| _version_ | 1829136777479192576 |
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| author | Isobel C. Mouat Marc S. Horwitz |
| author_facet | Isobel C. Mouat Marc S. Horwitz |
| author_sort | Isobel C. Mouat |
| collection | DOAJ |
| description | Age-associated B cells (ABCs) are a recently identified, unique B cell population that displays both protective and pathogenic characteristics, depending on the context. A major role of ABCs is to protect from viral infection. ABCs expand during an array of viral infections and display various functional capacities, including secretion of antibodies and activation of T cells. Following resolution of infection, ABCs appear to persist and play a crucial role in memory and recall responses. Here, we review the currently understanding of ABCs in the antiviral response in both humans and mice. We discuss avenues for future research, including the impact of sex on the ABC population and heterogeneity of ABCs between contexts. |
| first_indexed | 2024-12-14T18:48:55Z |
| format | Article |
| id | doaj.art-3defb3ece4aa44dd844dc68536ecdf86 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-14T18:48:55Z |
| publishDate | 2022-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-3defb3ece4aa44dd844dc68536ecdf862022-12-21T22:51:19ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742022-03-01183Age-associated B cells in viral infectionIsobel C. MouatMarc S. HorwitzAge-associated B cells (ABCs) are a recently identified, unique B cell population that displays both protective and pathogenic characteristics, depending on the context. A major role of ABCs is to protect from viral infection. ABCs expand during an array of viral infections and display various functional capacities, including secretion of antibodies and activation of T cells. Following resolution of infection, ABCs appear to persist and play a crucial role in memory and recall responses. Here, we review the currently understanding of ABCs in the antiviral response in both humans and mice. We discuss avenues for future research, including the impact of sex on the ABC population and heterogeneity of ABCs between contexts.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929649/?tool=EBI |
| spellingShingle | Isobel C. Mouat Marc S. Horwitz Age-associated B cells in viral infection PLoS Pathogens |
| title | Age-associated B cells in viral infection |
| title_full | Age-associated B cells in viral infection |
| title_fullStr | Age-associated B cells in viral infection |
| title_full_unstemmed | Age-associated B cells in viral infection |
| title_short | Age-associated B cells in viral infection |
| title_sort | age associated b cells in viral infection |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929649/?tool=EBI |
| work_keys_str_mv | AT isobelcmouat ageassociatedbcellsinviralinfection AT marcshorwitz ageassociatedbcellsinviralinfection |