Histological and morphological development of the prepuce from birth to prepubertal age
Purpose: To study the histological changes of the preputial tissue from birth to prepubertal age in order to define unnoticed morphological changes. Materials and Methods: Prepuce samples were obtained from 79 healthy boys who underwent routine ritual circumcision. Specimens were divided into six g...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2024-03-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20230034 |
| _version_ | 1827324770802204672 |
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| author | Erim Erdem Mustafa Kaplan Caliskan Meryem Ilkay Karagul Erdem Akbay Banu Coskun Yilmaz Yuksel Cem Aygun |
| author_facet | Erim Erdem Mustafa Kaplan Caliskan Meryem Ilkay Karagul Erdem Akbay Banu Coskun Yilmaz Yuksel Cem Aygun |
| author_sort | Erim Erdem |
| collection | DOAJ |
| description | Purpose: To study the histological changes of the preputial tissue from birth to prepubertal age in order to define unnoticed morphological changes.
Materials and Methods: Prepuce samples were obtained from 79 healthy boys who underwent routine ritual circumcision. Specimens were divided into six groups according to the boys’ age: newborn, 0–1 year of age, 2–3 years of age, 4–5 years of age, 6–7 years of age, and 8–9 years of age. Histologic analysis of the specimens was performed by H&E, Masson’s trichrome, Verhoeff–Von Gieson, immunohistochemical staining.
Results: Microscopic examinations showed that average epithelial thickness increased after the neonatal period (p=0.001). When collagen fiber density was evaluated, no significant differences between groups were found (p=0.083). When the elastic fibers in the dermis were evaluated, it was determined that the number and thickness of elastic fibers increased with age. Immunohistochemical examinations showed that the number of peripheral nerves marked with S100 was lower in the neonatal period than at other ages (p=0.048). When the vessels marked with CD105 antibody were counted, there was no significant difference between the groups (p=0.078).
Conclusions: This is the first study to examine the age-related structure of connective tissue elements in the foreskin. Our results showed that the prepuce’s prepubertal maturation process is continuous, and the first 2 years of life are appropriate not only in relation to the physiological effects of age but also the optimum structural changes for wound healing, such as vessel diameter, epithelium thickness, peripheral nerve count. |
| first_indexed | 2024-03-07T14:01:55Z |
| format | Article |
| id | doaj.art-3defb760445a463ab5cb2864ab6d2e66 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-03-07T14:01:55Z |
| publishDate | 2024-03-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-3defb760445a463ab5cb2864ab6d2e662024-03-07T05:23:43ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2024-03-0165218018810.4111/icu.20230034Histological and morphological development of the prepuce from birth to prepubertal ageErim Erdem0https://orcid.org/0000-0003-1754-4365Mustafa Kaplan Caliskan1https://orcid.org/0000-0003-0934-542XMeryem Ilkay Karagul 2https://orcid.org/0000-0002-1990-2640Erdem Akbay3https://orcid.org/0000-0001-7669-414XBanu Coskun Yilmaz4https://orcid.org/0000-0002-7723-9146Yuksel Cem Aygun5https://orcid.org/0000-0002-6232-4313Department of Urology, Mersin University Faculty of Medicine, Mersin, Türkiye.Department of Urology, Mersin University Faculty of Medicine, Mersin, Türkiye.Department of Histology and Embryology, Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Türkiye.Department of Urology, Mersin University Faculty of Medicine, Mersin, Türkiye.Department of Histology and Embryology, Mersin University Faculty of Medicine, Mersin, Türkiye.Department of Urology, Başkent University Faculty of Medicine, Ankara, Türkiye.Purpose: To study the histological changes of the preputial tissue from birth to prepubertal age in order to define unnoticed morphological changes. Materials and Methods: Prepuce samples were obtained from 79 healthy boys who underwent routine ritual circumcision. Specimens were divided into six groups according to the boys’ age: newborn, 0–1 year of age, 2–3 years of age, 4–5 years of age, 6–7 years of age, and 8–9 years of age. Histologic analysis of the specimens was performed by H&E, Masson’s trichrome, Verhoeff–Von Gieson, immunohistochemical staining. Results: Microscopic examinations showed that average epithelial thickness increased after the neonatal period (p=0.001). When collagen fiber density was evaluated, no significant differences between groups were found (p=0.083). When the elastic fibers in the dermis were evaluated, it was determined that the number and thickness of elastic fibers increased with age. Immunohistochemical examinations showed that the number of peripheral nerves marked with S100 was lower in the neonatal period than at other ages (p=0.048). When the vessels marked with CD105 antibody were counted, there was no significant difference between the groups (p=0.078). Conclusions: This is the first study to examine the age-related structure of connective tissue elements in the foreskin. Our results showed that the prepuce’s prepubertal maturation process is continuous, and the first 2 years of life are appropriate not only in relation to the physiological effects of age but also the optimum structural changes for wound healing, such as vessel diameter, epithelium thickness, peripheral nerve count.https://www.icurology.org/pdf/10.4111/icu.20230034androgenforeskinhypospadiasimmunohistochemistryperipheral nerves |
| spellingShingle | Erim Erdem Mustafa Kaplan Caliskan Meryem Ilkay Karagul Erdem Akbay Banu Coskun Yilmaz Yuksel Cem Aygun Histological and morphological development of the prepuce from birth to prepubertal age Investigative and Clinical Urology androgen foreskin hypospadias immunohistochemistry peripheral nerves |
| title | Histological and morphological development of the prepuce from birth to prepubertal age |
| title_full | Histological and morphological development of the prepuce from birth to prepubertal age |
| title_fullStr | Histological and morphological development of the prepuce from birth to prepubertal age |
| title_full_unstemmed | Histological and morphological development of the prepuce from birth to prepubertal age |
| title_short | Histological and morphological development of the prepuce from birth to prepubertal age |
| title_sort | histological and morphological development of the prepuce from birth to prepubertal age |
| topic | androgen foreskin hypospadias immunohistochemistry peripheral nerves |
| url | https://www.icurology.org/pdf/10.4111/icu.20230034 |
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