Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho
The paper deals with the analysis of studies of the role of the bone morphogenetic proteins fibroblast growth factor 23 (FGF-23) and Klothno in the development of vascular wall calcification in chronic renal disease (CRD). FGF-23 is shown to be an important phosphaturic hormone that inhibits hyperca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2010-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30642 |
| _version_ | 1818258883957751808 |
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| author | L Yu Milovanova L V Kozlovskaya Yu S Milovanov I N Bobkova I A Dobrosmyslov |
| author_facet | L Yu Milovanova L V Kozlovskaya Yu S Milovanov I N Bobkova I A Dobrosmyslov |
| author_sort | L Yu Milovanova |
| collection | DOAJ |
| description | The paper deals with the analysis of studies of the role of the bone morphogenetic proteins fibroblast growth factor 23 (FGF-23) and Klothno in the development of vascular wall calcification in chronic renal disease (CRD). FGF-23 is shown to be an important phosphaturic hormone that inhibits hypercalcemic and hyperphosphatemic effects of elevated serum vitamin D concentrations. There is evidence that there is an association between high serum FGF-23 levels and vascular wall calcification irrespective of the content of phosphorus and parathyroid hormone. Most authors regard FGF-23 as a potential uremic toxin in patients with end-stage CRD. There are data that support the renoprotective value of the morphogenetic protein Klotho whose expression in CRD is decreased. |
| first_indexed | 2024-12-12T18:06:38Z |
| format | Article |
| id | doaj.art-3df07b7761444d7293621f86e876c764 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-12T18:06:38Z |
| publishDate | 2010-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-3df07b7761444d7293621f86e876c7642022-12-22T00:16:27Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422010-06-01826667227669Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and KlothoL Yu Milovanova0L V Kozlovskaya1Yu S Milovanov2I N Bobkova3I A Dobrosmyslov4I. M. Sechenov Moscow Medical AcademyI. M. Sechenov Moscow Medical AcademyI. M. Sechenov Moscow Medical AcademyI. M. Sechenov Moscow Medical AcademyI. M. Sechenov Moscow Medical AcademyThe paper deals with the analysis of studies of the role of the bone morphogenetic proteins fibroblast growth factor 23 (FGF-23) and Klothno in the development of vascular wall calcification in chronic renal disease (CRD). FGF-23 is shown to be an important phosphaturic hormone that inhibits hypercalcemic and hyperphosphatemic effects of elevated serum vitamin D concentrations. There is evidence that there is an association between high serum FGF-23 levels and vascular wall calcification irrespective of the content of phosphorus and parathyroid hormone. Most authors regard FGF-23 as a potential uremic toxin in patients with end-stage CRD. There are data that support the renoprotective value of the morphogenetic protein Klotho whose expression in CRD is decreased.https://ter-arkhiv.ru/0040-3660/article/view/30642chronic heart diseasehyperphosphatemiacalcificationmorphogenetic proteins |
| spellingShingle | L Yu Milovanova L V Kozlovskaya Yu S Milovanov I N Bobkova I A Dobrosmyslov Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho Терапевтический архив chronic heart disease hyperphosphatemia calcification morphogenetic proteins |
| title | Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho |
| title_full | Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho |
| title_fullStr | Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho |
| title_full_unstemmed | Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho |
| title_short | Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho |
| title_sort | mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases the role of fibroblast growth factor 23 and klotho |
| topic | chronic heart disease hyperphosphatemia calcification morphogenetic proteins |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30642 |
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