In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study
ABSTRACT BACKGROUND: The frequency of coronavirus disease 2019 (COVID-19) cases among asthmatics has been reported to be reduced. However, the findings regarding the association between asthma and the risk of severe COVID-19 have been divergent. OBJECTIVE: To investigate whether asthma is associat...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2022-08-01
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022000500651&tlng=en |
| _version_ | 1797995362588295168 |
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| author | Gabriela Accetta Rojas Flávia Nascimento Ost Roberto Stirbulov Ozíris Simões |
| author_facet | Gabriela Accetta Rojas Flávia Nascimento Ost Roberto Stirbulov Ozíris Simões |
| author_sort | Gabriela Accetta Rojas |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: The frequency of coronavirus disease 2019 (COVID-19) cases among asthmatics has been reported to be reduced. However, the findings regarding the association between asthma and the risk of severe COVID-19 have been divergent. OBJECTIVE: To investigate whether asthma is associated with a reduced risk of development of severe COVID-19. DESIGN AND SETTING: Retrospective analysis on COVID-19 surveillance databases at two tertiary-level hospitals in São Paulo, Brazil. METHODS: The medical records of patients hospitalized due to COVID-19 between March and August 2020 were reviewed in accordance with the clinical, laboratorial, radiological and epidemiological criteria for COVID-19, and for comorbidities. RESULTS: Among the adult patients included (> 18 years of age) there were 52 asthmatics and 1,318 non-asthmatics. Their median ages and interquartile ranges (IQR) were, respectively, 54 (41-69) and 60 (44-72) years. At least one comorbidity was seen in 73% of asthmatics and 56% of the non-asthmatics. Among the asthmatics, most presented mild asthma (92%) and the prevalence of chronic obstructive pulmonary disease (COPD) was high (27%). The asthmatics presented an unadjusted odds ratio (OR) for severe COVID-19 of 0.89 (95% confidence interval, CI 0.5-1.56); and OR 0.88 (95% CI 0.5 -1.68) after multivariable adjustment. Age > 60 years, male sex, hypertension, diabetes, cancer and homelessness were covariates associated with increased odds for severe COVID-19. Kaplan-Meier estimated survival over hospitalization of up to 30 days did not differ between the groups (log-rank P = 0.09). CONCLUSIONS: The association between asthma and decreased risk of severe COVID-19 or increased survival was statistically non-significant. |
| first_indexed | 2024-04-11T09:59:16Z |
| format | Article |
| id | doaj.art-3df0ce135c45439d8161a2c37319635b |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-04-11T09:59:16Z |
| publishDate | 2022-08-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-3df0ce135c45439d8161a2c37319635b2022-12-22T04:30:27ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602022-08-01140565165710.1590/1516-3180.2021.0403.r2.15122021In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective studyGabriela Accetta Rojashttps://orcid.org/0000-0001-5747-0474Flávia Nascimento Osthttps://orcid.org/0000-0002-5873-9575Roberto Stirbulovhttps://orcid.org/0000-0003-0841-8105Ozíris Simõeshttps://orcid.org/0000-0002-1608-0469ABSTRACT BACKGROUND: The frequency of coronavirus disease 2019 (COVID-19) cases among asthmatics has been reported to be reduced. However, the findings regarding the association between asthma and the risk of severe COVID-19 have been divergent. OBJECTIVE: To investigate whether asthma is associated with a reduced risk of development of severe COVID-19. DESIGN AND SETTING: Retrospective analysis on COVID-19 surveillance databases at two tertiary-level hospitals in São Paulo, Brazil. METHODS: The medical records of patients hospitalized due to COVID-19 between March and August 2020 were reviewed in accordance with the clinical, laboratorial, radiological and epidemiological criteria for COVID-19, and for comorbidities. RESULTS: Among the adult patients included (> 18 years of age) there were 52 asthmatics and 1,318 non-asthmatics. Their median ages and interquartile ranges (IQR) were, respectively, 54 (41-69) and 60 (44-72) years. At least one comorbidity was seen in 73% of asthmatics and 56% of the non-asthmatics. Among the asthmatics, most presented mild asthma (92%) and the prevalence of chronic obstructive pulmonary disease (COPD) was high (27%). The asthmatics presented an unadjusted odds ratio (OR) for severe COVID-19 of 0.89 (95% confidence interval, CI 0.5-1.56); and OR 0.88 (95% CI 0.5 -1.68) after multivariable adjustment. Age > 60 years, male sex, hypertension, diabetes, cancer and homelessness were covariates associated with increased odds for severe COVID-19. Kaplan-Meier estimated survival over hospitalization of up to 30 days did not differ between the groups (log-rank P = 0.09). CONCLUSIONS: The association between asthma and decreased risk of severe COVID-19 or increased survival was statistically non-significant.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022000500651&tlng=enAsthmaCOVID-19SARS-CoV-2HospitalizationDeathSevere COVID-19Philanthropic tertiary hospitalNeed for intubation |
| spellingShingle | Gabriela Accetta Rojas Flávia Nascimento Ost Roberto Stirbulov Ozíris Simões In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study São Paulo Medical Journal Asthma COVID-19 SARS-CoV-2 Hospitalization Death Severe COVID-19 Philanthropic tertiary hospital Need for intubation |
| title | In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study |
| title_full | In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study |
| title_fullStr | In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study |
| title_full_unstemmed | In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study |
| title_short | In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study |
| title_sort | in hospital severe covid 19 in a philanthropic tertiary hospital setting is asthma a concern a retrospective study |
| topic | Asthma COVID-19 SARS-CoV-2 Hospitalization Death Severe COVID-19 Philanthropic tertiary hospital Need for intubation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022000500651&tlng=en |
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