Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines

4-(3-(4-Substituted-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamides (9–16) were successfully synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, and HRMS spectra. Carbonic anhydrase I and II inhibitory effects of the compounds were investigated. Ki values o...

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Bibliographic Details
Main Authors:	Halise Inci Gul, Ebru Mete, Parham Taslimi, Ilhami Gulcin, Claudiu T. Supuran
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	Carbonic anhydrase enzyme pyrazoline sulfonamide
Online Access:	http://dx.doi.org/10.1080/14756366.2016.1244533

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