Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis
Aim Idiopathic membranous nephropathy (IMN) is a common type of nephrotic syndrome, and is associated with acute kidney injury (AKI). We investigated the association of multiple variables with AKI in patients with IMN.Methods The data of 187 patients with biopsy-proven IMN were examined. Renal outco...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2194451 |
| _version_ | 1826900362821369856 |
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| author | Zhenzhou Li Mengjie Weng Lizhao Lin Yi Chen Jiaqun Lin Jiong Cui Dewen Jiang Binbin Fu Guifen Li Caiming Chen Yanfang Xu Jianxin Wan |
| author_facet | Zhenzhou Li Mengjie Weng Lizhao Lin Yi Chen Jiaqun Lin Jiong Cui Dewen Jiang Binbin Fu Guifen Li Caiming Chen Yanfang Xu Jianxin Wan |
| author_sort | Zhenzhou Li |
| collection | DOAJ |
| description | Aim Idiopathic membranous nephropathy (IMN) is a common type of nephrotic syndrome, and is associated with acute kidney injury (AKI). We investigated the association of multiple variables with AKI in patients with IMN.Methods The data of 187 patients with biopsy-proven IMN were examined. Renal outcome was defined as progression to end-stage renal disease (ESRD). Binary logistic regression and Kaplan–Meier’s analysis were used for statistical analysis.Results During follow-up, 46 (24.6%) patients developed AKI. The incidence of AKI was greater in males than females (p < .01). The AKI group had higher uric acid, lower serum PLA2R antibody positive, and worse baseline kidney function (all p < .01). Most patients in the AKI group had stage I (71.74%) or stage II (21.74%). The AKI group had higher renal tubular injury score and chronicity index (both p < .05). Binary logistic regression indicated that uric acid and baseline estimated glomerular filtration rate (eGFR) were independent risk factors for AKI in patients with IMN (p < .05). The optimal cutoff value of serum uric acid for predicting AKI was 402.50 μmol/L and the baseline eGFR was 96.83 mL/min/1.73 m2. Kaplan–Meier’s analysis showed that the cumulative renal survival rate was lower in the AKI group (p = .047).Conclusions AKI increases the risk of poor prognosis in IMN patients and the high uric acid and low baseline eGFR were considered independent predictors for developing AKI in patients with IMN. |
| first_indexed | 2024-03-11T17:59:47Z |
| format | Article |
| id | doaj.art-3df4fab4080e4d45865706dae2b4d9cb |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2025-02-17T07:07:31Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-3df4fab4080e4d45865706dae2b4d9cb2025-01-06T03:21:20ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2194451Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosisZhenzhou Li0Mengjie Weng1Lizhao Lin2Yi Chen3Jiaqun Lin4Jiong Cui5Dewen Jiang6Binbin Fu7Guifen Li8Caiming Chen9Yanfang Xu10Jianxin Wan11Department of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaAim Idiopathic membranous nephropathy (IMN) is a common type of nephrotic syndrome, and is associated with acute kidney injury (AKI). We investigated the association of multiple variables with AKI in patients with IMN.Methods The data of 187 patients with biopsy-proven IMN were examined. Renal outcome was defined as progression to end-stage renal disease (ESRD). Binary logistic regression and Kaplan–Meier’s analysis were used for statistical analysis.Results During follow-up, 46 (24.6%) patients developed AKI. The incidence of AKI was greater in males than females (p < .01). The AKI group had higher uric acid, lower serum PLA2R antibody positive, and worse baseline kidney function (all p < .01). Most patients in the AKI group had stage I (71.74%) or stage II (21.74%). The AKI group had higher renal tubular injury score and chronicity index (both p < .05). Binary logistic regression indicated that uric acid and baseline estimated glomerular filtration rate (eGFR) were independent risk factors for AKI in patients with IMN (p < .05). The optimal cutoff value of serum uric acid for predicting AKI was 402.50 μmol/L and the baseline eGFR was 96.83 mL/min/1.73 m2. Kaplan–Meier’s analysis showed that the cumulative renal survival rate was lower in the AKI group (p = .047).Conclusions AKI increases the risk of poor prognosis in IMN patients and the high uric acid and low baseline eGFR were considered independent predictors for developing AKI in patients with IMN.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2194451Acute kidney injuryidiopathic membranous nephropathybiopsyprognosis |
| spellingShingle | Zhenzhou Li Mengjie Weng Lizhao Lin Yi Chen Jiaqun Lin Jiong Cui Dewen Jiang Binbin Fu Guifen Li Caiming Chen Yanfang Xu Jianxin Wan Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis Renal Failure Acute kidney injury idiopathic membranous nephropathy biopsy prognosis |
| title | Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis |
| title_full | Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis |
| title_fullStr | Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis |
| title_full_unstemmed | Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis |
| title_short | Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis |
| title_sort | acute kidney injury in patients with idiopathic membranous nephropathy influencing factors and prognosis |
| topic | Acute kidney injury idiopathic membranous nephropathy biopsy prognosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2194451 |
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