Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort study
Abstract Background Stroke is a leading cause of mortality and disability worldwide and its occurrence is expected to increase in the future. Blood biomarkers have proven their usefulness in identification and monitoring of the disease. Stroke severity is a major factor for estimation of prognosis a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Neurological Research and Practice |
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| Online Access: | https://doi.org/10.1186/s42466-023-00259-3 |
| _version_ | 1797773877401616384 |
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| author | Lino Braadt Markus Naumann Dennis Freuer Timo Schmitz Jakob Linseisen Michael Ertl |
| author_facet | Lino Braadt Markus Naumann Dennis Freuer Timo Schmitz Jakob Linseisen Michael Ertl |
| author_sort | Lino Braadt |
| collection | DOAJ |
| description | Abstract Background Stroke is a leading cause of mortality and disability worldwide and its occurrence is expected to increase in the future. Blood biomarkers have proven their usefulness in identification and monitoring of the disease. Stroke severity is a major factor for estimation of prognosis and risk of recurrent events, but knowledge on respective blood biomarkers is still scarce. Stroke pathophysiology comprises a multitude of ischemia-induced inflammatory and immune mediated responses. Therefore, the assessment of an immune-related panel in correlation with stroke severity seems promising. Methods In the present cross-sectional evaluation, a set of 92 blood biomarkers of a standardized immune panel were gathered (median 4.6 days after admission) and related to stroke severity measures, assessed at hospital admission of acute stroke patients. Multivariable logistic regression models were used to determine associations between biomarkers and modified Rankin Scale (mRS), linear regression models were used for associations with National Institute of Health Stroke Scale. Results 415 patients (mean age 69 years; 41% female) were included for biomarker analysis. C-type lectin domain family 4 member G (CLEC4G; OR = 2.89, 95% CI [1.49; 5.59], p adj = 0.026, Cytoskeleton-associated protein 4 (CKAP4; OR = 2.38, 95% CI [1.43; 3.98], p adj = 0.019), and Interleukin-6 (IL-6) (IL6; OR = 1.97, 95% CI [1.49; 2.62], p adj < 0.001) were positively associated with stroke severity measured by mRS, while Lymphocyte antigen 75 (LY75; OR = 0.37, 95% CI [0.19; 0.73], p adj = 0.049) and Integrin alpha-11 (ITGA11 OR = 0.24, 95% CI [0.14, 0.40] p adj < 0.001) were inversely associated. When investigating the relationships with the NIHSS, IL-6 (β = 0.23, 95% CI [0.12, 0.33] p adj = 0.001) and ITGA11 (β = − 0.60, 95% CI [− 0.83, − 0.37] p adj < 0.001) were significantly associated. Conclusions Higher relative concentrations of plasma CLEC4G, CKAP4, and IL-6 were associated with higher stroke severity, whereas LY75 and ITGA11 showed an inverse association. Future research might show a possible use as therapeutic targets and application in individual risk assessments. |
| first_indexed | 2024-03-12T22:12:15Z |
| format | Article |
| id | doaj.art-3df556a444734deca1912bd9e653849e |
| institution | Directory Open Access Journal |
| issn | 2524-3489 |
| language | English |
| last_indexed | 2024-03-12T22:12:15Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Neurological Research and Practice |
| spelling | doaj.art-3df556a444734deca1912bd9e653849e2023-07-23T11:30:15ZengBMCNeurological Research and Practice2524-34892023-07-015111010.1186/s42466-023-00259-3Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort studyLino Braadt0Markus Naumann1Dennis Freuer2Timo Schmitz3Jakob Linseisen4Michael Ertl5Department of Neurology and Clinical Neurophysiology, University Hospital AugsburgDepartment of Neurology and Clinical Neurophysiology, University Hospital AugsburgEpidemiology, Faculty of Medicine, University of AugsburgEpidemiology, Faculty of Medicine, University of AugsburgEpidemiology, Faculty of Medicine, University of AugsburgDepartment of Neurology and Clinical Neurophysiology, University Hospital AugsburgAbstract Background Stroke is a leading cause of mortality and disability worldwide and its occurrence is expected to increase in the future. Blood biomarkers have proven their usefulness in identification and monitoring of the disease. Stroke severity is a major factor for estimation of prognosis and risk of recurrent events, but knowledge on respective blood biomarkers is still scarce. Stroke pathophysiology comprises a multitude of ischemia-induced inflammatory and immune mediated responses. Therefore, the assessment of an immune-related panel in correlation with stroke severity seems promising. Methods In the present cross-sectional evaluation, a set of 92 blood biomarkers of a standardized immune panel were gathered (median 4.6 days after admission) and related to stroke severity measures, assessed at hospital admission of acute stroke patients. Multivariable logistic regression models were used to determine associations between biomarkers and modified Rankin Scale (mRS), linear regression models were used for associations with National Institute of Health Stroke Scale. Results 415 patients (mean age 69 years; 41% female) were included for biomarker analysis. C-type lectin domain family 4 member G (CLEC4G; OR = 2.89, 95% CI [1.49; 5.59], p adj = 0.026, Cytoskeleton-associated protein 4 (CKAP4; OR = 2.38, 95% CI [1.43; 3.98], p adj = 0.019), and Interleukin-6 (IL-6) (IL6; OR = 1.97, 95% CI [1.49; 2.62], p adj < 0.001) were positively associated with stroke severity measured by mRS, while Lymphocyte antigen 75 (LY75; OR = 0.37, 95% CI [0.19; 0.73], p adj = 0.049) and Integrin alpha-11 (ITGA11 OR = 0.24, 95% CI [0.14, 0.40] p adj < 0.001) were inversely associated. When investigating the relationships with the NIHSS, IL-6 (β = 0.23, 95% CI [0.12, 0.33] p adj = 0.001) and ITGA11 (β = − 0.60, 95% CI [− 0.83, − 0.37] p adj < 0.001) were significantly associated. Conclusions Higher relative concentrations of plasma CLEC4G, CKAP4, and IL-6 were associated with higher stroke severity, whereas LY75 and ITGA11 showed an inverse association. Future research might show a possible use as therapeutic targets and application in individual risk assessments.https://doi.org/10.1186/s42466-023-00259-3StrokeBiomarkersFunctional outcomeStroke severity |
| spellingShingle | Lino Braadt Markus Naumann Dennis Freuer Timo Schmitz Jakob Linseisen Michael Ertl Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort study Neurological Research and Practice Stroke Biomarkers Functional outcome Stroke severity |
| title | Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort study |
| title_full | Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort study |
| title_fullStr | Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort study |
| title_full_unstemmed | Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort study |
| title_short | Novel inflammatory biomarkers associated with stroke severity: results from a cross-sectional stroke cohort study |
| title_sort | novel inflammatory biomarkers associated with stroke severity results from a cross sectional stroke cohort study |
| topic | Stroke Biomarkers Functional outcome Stroke severity |
| url | https://doi.org/10.1186/s42466-023-00259-3 |
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