Inhibition of Polyamine Biosynthesis Reverses Ca2+ Channel Remodeling in Colon Cancer Cells

Inhibition of Polyamine Biosynthesis Reverses Ca2+ Channel Remodeling in Colon Cancer Cells

Store-operated Ca2+ entry (SOCE) is the most important Ca2+ entry pathway in non-excitable cells. Colorectal cancer (CRC) shows decreased Ca2+ store content and enhanced SOCE that correlate with cancer hallmarks and are associated to remodeling of store-operated channels (SOCs). Normal colonic cells...

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Bibliographic Details
Main Authors:	Lucía G. Gutiérrez, Miriam Hernández-Morales, Lucía Núñez, Carlos Villalobos
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Cancers
Subjects:	colorectal cancer DFMO store-operated Ca2+ entry store-operated currents polyamines TRPC1 sulindac
Online Access:	http://www.mdpi.com/2072-6694/11/1/83

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