Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity
Summary: Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively described; however, the immunological landscape of the term decidua remains poorly understood. We therefore profiled human leukocytes from term decidua collected via scheduled cesarean delivery. Relativ...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723007805 |
| _version_ | 1797783581815209984 |
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| author | Suhas Sureshchandra Brianna M. Doratt Heather True Norma Mendoza Monica Rincon Nicole E. Marshall Ilhem Messaoudi |
| author_facet | Suhas Sureshchandra Brianna M. Doratt Heather True Norma Mendoza Monica Rincon Nicole E. Marshall Ilhem Messaoudi |
| author_sort | Suhas Sureshchandra |
| collection | DOAJ |
| description | Summary: Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively described; however, the immunological landscape of the term decidua remains poorly understood. We therefore profiled human leukocytes from term decidua collected via scheduled cesarean delivery. Relative to the first trimester, our analyses show a shift from NK cells and macrophages to T cells and enhanced immune activation. Although circulating and decidual T cells are phenotypically distinct, they demonstrate significant clonotype sharing. We also report significant diversity within decidual macrophages, the frequency of which positively correlates with pregravid maternal body mass index. Interestingly, the ability of decidual macrophages to respond to bacterial ligands is reduced with pregravid obesity, suggestive of skewing toward immunoregulation as a possible mechanism to safeguard the fetus against excessive maternal inflammation. These findings are a resource for future studies investigating pathological conditions that compromise fetal health and reproductive success. |
| first_indexed | 2024-03-13T00:27:55Z |
| format | Article |
| id | doaj.art-3df72ef0dbb14199842331839338a907 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-13T00:27:55Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-3df72ef0dbb14199842331839338a9072023-07-11T04:06:20ZengElsevierCell Reports2211-12472023-07-01427112769Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesitySuhas Sureshchandra0Brianna M. Doratt1Heather True2Norma Mendoza3Monica Rincon4Nicole E. Marshall5Ilhem Messaoudi6Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USADepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USADepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USAInstitute for Immunology, University of California, Irvine, Irvine, CA 92697, USAMaternal-Fetal Medicine, Oregon Health and Science University, Portland, OR 97239, USAMaternal-Fetal Medicine, Oregon Health and Science University, Portland, OR 97239, USAInstitute for Immunology, University of California, Irvine, Irvine, CA 92697, USA; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA; Corresponding authorSummary: Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively described; however, the immunological landscape of the term decidua remains poorly understood. We therefore profiled human leukocytes from term decidua collected via scheduled cesarean delivery. Relative to the first trimester, our analyses show a shift from NK cells and macrophages to T cells and enhanced immune activation. Although circulating and decidual T cells are phenotypically distinct, they demonstrate significant clonotype sharing. We also report significant diversity within decidual macrophages, the frequency of which positively correlates with pregravid maternal body mass index. Interestingly, the ability of decidual macrophages to respond to bacterial ligands is reduced with pregravid obesity, suggestive of skewing toward immunoregulation as a possible mechanism to safeguard the fetus against excessive maternal inflammation. These findings are a resource for future studies investigating pathological conditions that compromise fetal health and reproductive success.http://www.sciencedirect.com/science/article/pii/S2211124723007805CP: Immunology |
| spellingShingle | Suhas Sureshchandra Brianna M. Doratt Heather True Norma Mendoza Monica Rincon Nicole E. Marshall Ilhem Messaoudi Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity Cell Reports CP: Immunology |
| title | Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity |
| title_full | Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity |
| title_fullStr | Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity |
| title_full_unstemmed | Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity |
| title_short | Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity |
| title_sort | multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723007805 |
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