Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria
Abstract Background The transcription factors (TFs) in thermophilic cyanobacteria might represent a uniquely evolved gene repertoire in light of the strong selective pressure caused by hostile habitats. Understanding the molecular composition of the TF genes in thermophilic cyanobacteria will facili...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-024-09969-7 |
| _version_ | 1797355976069742592 |
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| author | Jie Tang Zhe Hu Jing Zhang Maurycy Daroch |
| author_facet | Jie Tang Zhe Hu Jing Zhang Maurycy Daroch |
| author_sort | Jie Tang |
| collection | DOAJ |
| description | Abstract Background The transcription factors (TFs) in thermophilic cyanobacteria might represent a uniquely evolved gene repertoire in light of the strong selective pressure caused by hostile habitats. Understanding the molecular composition of the TF genes in thermophilic cyanobacteria will facilitate further studies regarding verifying their exact biochemical functions and genetic engineering. However, limited information is available on the TFs of thermophilic cyanobacteria. Herein, a thorough investigation and comparative analysis were performed to gain insights into the molecular composition of the TFs in 22 thermophilic cyanobacteria. Results The results suggested a fascinating diversity of the TFs among these thermophiles. The abundance and type of TF genes were diversified in these genomes. The identified TFs are speculated to play various roles in biological regulations. Further comparative and evolutionary genomic analyses revealed that HGT may be associated with the genomic plasticity of TF genes in Thermostichus and Thermosynechococcus strains. Comparative analyses also indicated different pattern of TF composition between thermophiles and corresponding mesophilic reference cyanobacteria. Moreover, the identified unique TFs of thermophiles are putatively involved in various biological regulations, mainly as responses to ambient changes, may facilitating the thermophiles to survive in hot springs. Conclusion The findings herein shed light on the TFs of thermophilic cyanobacteria and fundamental knowledge for further research regarding thermophilic cyanobacteria with a broad potential for transcription regulations in responses to environmental fluctuations. |
| first_indexed | 2024-03-08T14:18:57Z |
| format | Article |
| id | doaj.art-3df781f828004145b8c869a0d72d5ef7 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-03-08T14:18:57Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-3df781f828004145b8c869a0d72d5ef72024-01-14T12:12:55ZengBMCBMC Genomics1471-21642024-01-0125111310.1186/s12864-024-09969-7Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteriaJie Tang0Zhe Hu1Jing Zhang2Maurycy Daroch3School of Pharmacy and Bioengineering, Chengdu UniversitySchool of Pharmacy and Bioengineering, Chengdu UniversityFood Safety Detection Key Laboratory of Sichuan, Technical Center of Chengdu CustomsSchool of Environment and Energy, Peking University Shenzhen Graduate SchoolAbstract Background The transcription factors (TFs) in thermophilic cyanobacteria might represent a uniquely evolved gene repertoire in light of the strong selective pressure caused by hostile habitats. Understanding the molecular composition of the TF genes in thermophilic cyanobacteria will facilitate further studies regarding verifying their exact biochemical functions and genetic engineering. However, limited information is available on the TFs of thermophilic cyanobacteria. Herein, a thorough investigation and comparative analysis were performed to gain insights into the molecular composition of the TFs in 22 thermophilic cyanobacteria. Results The results suggested a fascinating diversity of the TFs among these thermophiles. The abundance and type of TF genes were diversified in these genomes. The identified TFs are speculated to play various roles in biological regulations. Further comparative and evolutionary genomic analyses revealed that HGT may be associated with the genomic plasticity of TF genes in Thermostichus and Thermosynechococcus strains. Comparative analyses also indicated different pattern of TF composition between thermophiles and corresponding mesophilic reference cyanobacteria. Moreover, the identified unique TFs of thermophiles are putatively involved in various biological regulations, mainly as responses to ambient changes, may facilitating the thermophiles to survive in hot springs. Conclusion The findings herein shed light on the TFs of thermophilic cyanobacteria and fundamental knowledge for further research regarding thermophilic cyanobacteria with a broad potential for transcription regulations in responses to environmental fluctuations.https://doi.org/10.1186/s12864-024-09969-7Thermophilic cyanobacteriumTranscription factorComparative genomics |
| spellingShingle | Jie Tang Zhe Hu Jing Zhang Maurycy Daroch Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria BMC Genomics Thermophilic cyanobacterium Transcription factor Comparative genomics |
| title | Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria |
| title_full | Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria |
| title_fullStr | Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria |
| title_full_unstemmed | Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria |
| title_short | Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria |
| title_sort | genome scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria |
| topic | Thermophilic cyanobacterium Transcription factor Comparative genomics |
| url | https://doi.org/10.1186/s12864-024-09969-7 |
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