Effects of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on a diabetic neuropathic pain model

Effects of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on a diabetic neuropathic pain model

Background: Neuropathy is a prevalent and debilitating complication of poorly managed diabetes, contributing towards poor quality of life, amputation risk, and increased mortality. The available therapies for diabetic neuropathic pain (DPN) have limitations in terms of efficacy, tolerability and pat...

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Bibliographic Details
Main Authors: Ahmed Tokhi, Zainab Ahmed, Mehreen Arif, Naeem Ur Rehman, Vahid Sheibani, Robert D. E. Sewell, Khalid Rauf
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
diabetic neuropathic pain
1-methyl-1,2,3,4-tetrahydroisoquinoline
hyperalgesia
allodynia
tail immersion test
von frey filaments
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1128496/full

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