A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy

Super-resolution microscopy is a powerful tool for cellular studies but requires bright and stable fluorescent probes. Here, the authors report on a strategy to introduce quinoxaline motifs to conventional probes to make them brighter, more photostable, larger Stokes shift, and demonstrate the probe...

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Main Authors: Gangwei Jiang, Tian-Bing Ren, Elisa D’Este, Mengyi Xiong, Bin Xiong, Kai Johnsson, Xiao-Bing Zhang, Lu Wang, Lin Yuan
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29547-3
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author Gangwei Jiang
Tian-Bing Ren
Elisa D’Este
Mengyi Xiong
Bin Xiong
Kai Johnsson
Xiao-Bing Zhang
Lu Wang
Lin Yuan
author_facet Gangwei Jiang
Tian-Bing Ren
Elisa D’Este
Mengyi Xiong
Bin Xiong
Kai Johnsson
Xiao-Bing Zhang
Lu Wang
Lin Yuan
author_sort Gangwei Jiang
collection DOAJ
description Super-resolution microscopy is a powerful tool for cellular studies but requires bright and stable fluorescent probes. Here, the authors report on a strategy to introduce quinoxaline motifs to conventional probes to make them brighter, more photostable, larger Stokes shift, and demonstrate the probes for biosensing applications.
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spelling doaj.art-3df8a774d0cd4bbb99426b81279637532022-12-22T02:35:39ZengNature PortfolioNature Communications2041-17232022-04-0113111010.1038/s41467-022-29547-3A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopyGangwei Jiang0Tian-Bing Ren1Elisa D’Este2Mengyi Xiong3Bin Xiong4Kai Johnsson5Xiao-Bing Zhang6Lu Wang7Lin Yuan8State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan UniversityState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan UniversityOptical Microscopy Facility, Max Planck Institute for Medical ResearchState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan UniversityState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan UniversityDepartment of Chemical Biology, Max Planck Institute for Medical ResearchState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan UniversityDepartment of Chemical Biology, Max Planck Institute for Medical ResearchState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan UniversitySuper-resolution microscopy is a powerful tool for cellular studies but requires bright and stable fluorescent probes. Here, the authors report on a strategy to introduce quinoxaline motifs to conventional probes to make them brighter, more photostable, larger Stokes shift, and demonstrate the probes for biosensing applications.https://doi.org/10.1038/s41467-022-29547-3
spellingShingle Gangwei Jiang
Tian-Bing Ren
Elisa D’Este
Mengyi Xiong
Bin Xiong
Kai Johnsson
Xiao-Bing Zhang
Lu Wang
Lin Yuan
A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
Nature Communications
title A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
title_full A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
title_fullStr A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
title_full_unstemmed A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
title_short A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
title_sort synergistic strategy to develop photostable and bright dyes with long stokes shift for nanoscopy
url https://doi.org/10.1038/s41467-022-29547-3
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