Short‐term GAA loading: Responders versus nonresponders analysis

Abstract Dietary guanidinoacetic acid (GAA) has been suggested to be advantageous for favorable changes in tissue bioenergetics in terms of responder versus nonresponder performance, yet no studies so far explored the proportion of two distinct populations following short‐term GAA intervention. A se...

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Main Author: Sergej M. Ostojic
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Food Science & Nutrition
Subjects:
Online Access:https://doi.org/10.1002/fsn3.1744
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author Sergej M. Ostojic
author_facet Sergej M. Ostojic
author_sort Sergej M. Ostojic
collection DOAJ
description Abstract Dietary guanidinoacetic acid (GAA) has been suggested to be advantageous for favorable changes in tissue bioenergetics in terms of responder versus nonresponder performance, yet no studies so far explored the proportion of two distinct populations following short‐term GAA intervention. A secondary analysis of previously completed guanidinoacetic acid (GAA) trials has been carried out in aim to classify individuals into responders and nonresponders using cut‐off criteria for an increase in intramuscular creatine. A total of 30 individuals (mean age = 34.5 years, women 66.7%) who were supplemented with up to 3 g/day of GAA for at least 28 days with total muscle creatine evaluated using 1.5 T magnetic resonance spectroscopy studies were included in this examination. Pre–post measures included total creatine content (creatine plus phosphocreatine) determined from the quadriceps muscle, with participants were classified by arbitrary cut‐off points in three categories, including responders (>10% increase in total creatine content at follow‐up), quasi‐responders (5%–10% increase), and nonresponders (<5% increase in total intramuscular creatine at postadministration). An average change in total creatine content after GAA supplementation was 22.9%, with 13.3% participants were categorized as nonresponders, 6.6% as quasi‐responders, and 80.0% as responders (p < .001). A fairly high prevalence of individuals sensitive to dietary GAA advances this innovative agent as a rather effective tool to improve muscle creatine levels for at least 10% or more during 28‐day loading.
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spelling doaj.art-3df9f603e8834e73b22e91cb3db0d52d2023-10-12T12:06:11ZengWileyFood Science & Nutrition2048-71772020-08-01884446444810.1002/fsn3.1744Short‐term GAA loading: Responders versus nonresponders analysisSergej M. Ostojic0Faculty of Sport and Physical Education University of Novi Sad Novi Sad SerbiaAbstract Dietary guanidinoacetic acid (GAA) has been suggested to be advantageous for favorable changes in tissue bioenergetics in terms of responder versus nonresponder performance, yet no studies so far explored the proportion of two distinct populations following short‐term GAA intervention. A secondary analysis of previously completed guanidinoacetic acid (GAA) trials has been carried out in aim to classify individuals into responders and nonresponders using cut‐off criteria for an increase in intramuscular creatine. A total of 30 individuals (mean age = 34.5 years, women 66.7%) who were supplemented with up to 3 g/day of GAA for at least 28 days with total muscle creatine evaluated using 1.5 T magnetic resonance spectroscopy studies were included in this examination. Pre–post measures included total creatine content (creatine plus phosphocreatine) determined from the quadriceps muscle, with participants were classified by arbitrary cut‐off points in three categories, including responders (>10% increase in total creatine content at follow‐up), quasi‐responders (5%–10% increase), and nonresponders (<5% increase in total intramuscular creatine at postadministration). An average change in total creatine content after GAA supplementation was 22.9%, with 13.3% participants were categorized as nonresponders, 6.6% as quasi‐responders, and 80.0% as responders (p < .001). A fairly high prevalence of individuals sensitive to dietary GAA advances this innovative agent as a rather effective tool to improve muscle creatine levels for at least 10% or more during 28‐day loading.https://doi.org/10.1002/fsn3.1744creatineguanidinoacetic acidMR spectroscopymusclenon‐responderssupplementation
spellingShingle Sergej M. Ostojic
Short‐term GAA loading: Responders versus nonresponders analysis
Food Science & Nutrition
creatine
guanidinoacetic acid
MR spectroscopy
muscle
non‐responders
supplementation
title Short‐term GAA loading: Responders versus nonresponders analysis
title_full Short‐term GAA loading: Responders versus nonresponders analysis
title_fullStr Short‐term GAA loading: Responders versus nonresponders analysis
title_full_unstemmed Short‐term GAA loading: Responders versus nonresponders analysis
title_short Short‐term GAA loading: Responders versus nonresponders analysis
title_sort short term gaa loading responders versus nonresponders analysis
topic creatine
guanidinoacetic acid
MR spectroscopy
muscle
non‐responders
supplementation
url https://doi.org/10.1002/fsn3.1744
work_keys_str_mv AT sergejmostojic shorttermgaaloadingrespondersversusnonrespondersanalysis