Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex
Summary: The activation of anticancer molecules with visible light constitutes an elegant strategy to target tumors and to improve the selectivity of treatments. In this context, we report here a visible-light activatable bis-platinum complex (DHP-Pt2) incorporating an organic photo-switchable ligan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223027815 |
| _version_ | 1827397764018864128 |
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| author | Zakaria Ziani Saioa Cobo Nathalie Berthet Guy Royal |
| author_facet | Zakaria Ziani Saioa Cobo Nathalie Berthet Guy Royal |
| author_sort | Zakaria Ziani |
| collection | DOAJ |
| description | Summary: The activation of anticancer molecules with visible light constitutes an elegant strategy to target tumors and to improve the selectivity of treatments. In this context, we report here a visible-light activatable bis-platinum complex (DHP-Pt2) incorporating an organic photo-switchable ligand based on the dimethyldihydropyrene moiety. Illumination of this metal complex with red light (660 nm) under air readily produces the corresponding endoperoxide form (CPDO2-Pt2). These two metal complexes exhibit different DNA binding properties and, more importantly, we show that only the photogenerated CPDO2-Pt2 is able to penetrate into cancer cell nuclei, where it is then capable of releasing cytotoxic singlet oxygen. This study represents the first proof-of-concept showing that dimethyldihydropyrene derivatives can be used to transport and deliver singlet oxygen into cancer cell nuclei upon visible-light activation. |
| first_indexed | 2024-03-08T19:17:19Z |
| format | Article |
| id | doaj.art-3df9fdfd869c47c98ae30289caa6a011 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T19:17:19Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-3df9fdfd869c47c98ae30289caa6a0112023-12-27T05:28:44ZengElsevieriScience2589-00422024-01-01271108704Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complexZakaria Ziani0Saioa Cobo1Nathalie Berthet2Guy Royal3University Grenoble Alpes, CNRS, DCM, 38000 Grenoble, FranceUniversity Grenoble Alpes, CNRS, DCM, 38000 Grenoble, FranceUniversity Grenoble Alpes, CNRS, DCM, 38000 Grenoble, France; Corresponding authorUniversity Grenoble Alpes, CNRS, DCM, 38000 Grenoble, France; Corresponding authorSummary: The activation of anticancer molecules with visible light constitutes an elegant strategy to target tumors and to improve the selectivity of treatments. In this context, we report here a visible-light activatable bis-platinum complex (DHP-Pt2) incorporating an organic photo-switchable ligand based on the dimethyldihydropyrene moiety. Illumination of this metal complex with red light (660 nm) under air readily produces the corresponding endoperoxide form (CPDO2-Pt2). These two metal complexes exhibit different DNA binding properties and, more importantly, we show that only the photogenerated CPDO2-Pt2 is able to penetrate into cancer cell nuclei, where it is then capable of releasing cytotoxic singlet oxygen. This study represents the first proof-of-concept showing that dimethyldihydropyrene derivatives can be used to transport and deliver singlet oxygen into cancer cell nuclei upon visible-light activation.http://www.sciencedirect.com/science/article/pii/S2589004223027815ChemistryPhysicsBiological sciences |
| spellingShingle | Zakaria Ziani Saioa Cobo Nathalie Berthet Guy Royal Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex iScience Chemistry Physics Biological sciences |
| title | Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex |
| title_full | Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex |
| title_fullStr | Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex |
| title_full_unstemmed | Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex |
| title_short | Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex |
| title_sort | optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex |
| topic | Chemistry Physics Biological sciences |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223027815 |
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