Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers
Diabetic foot ulcers (DFUs) are classified as chronic wounds and are one of the most common complications of diabetes. In chronic wounds, management of inflammation is a key step in treatment. Nutrition plays an important role in managing and controlling inflammation. This study evaluated the effect...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/12/2393 |
| _version_ | 1797483658056040448 |
|---|---|
| author | Raedeh Basiri Maria Spicer Cathy Levenson Thomas Ledermann Neda Akhavan Bahram Arjmandi |
| author_facet | Raedeh Basiri Maria Spicer Cathy Levenson Thomas Ledermann Neda Akhavan Bahram Arjmandi |
| author_sort | Raedeh Basiri |
| collection | DOAJ |
| description | Diabetic foot ulcers (DFUs) are classified as chronic wounds and are one of the most common complications of diabetes. In chronic wounds, management of inflammation is a key step in treatment. Nutrition plays an important role in managing and controlling inflammation. This study evaluated the effects of nutrition supplementation and education on inflammatory biomarkers in patients with DFUs. Eligible patients with foot ulcers were randomly assigned to either a treatment (<i>n</i> = 15) or control group (<i>n</i> = 14). Both groups received standard care for wound treatment from the clinic; however, the treatment group was also provided with nutritional supplementation and education. Plasma concentrations of inflammatory biomarkers, namely C-reactive protein (CRP), interleukin 6 (IL6), interleukin 10 (IL10), and tristetraprolin (TTP), were evaluated at baseline and every four weeks, until complete wound closure had occurred or up to 12 weeks. The mean plasma concentration of IL6 significantly decreased in the treatment group (<i>p</i> = 0.001). The interaction between time and group was not statistically significant for the mean plasma concentrations of CRP, IL10, and TTP during the 12 weeks of the study. The results of this study showed the positive effects of nutritional intervention on controlling inflammation in DFU patients. More clinical trials with a larger population and longer duration of time are needed to confirm our results. |
| first_indexed | 2024-03-09T22:51:10Z |
| format | Article |
| id | doaj.art-3dfa2b742d4b4c10b96057b433e13771 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:51:10Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3dfa2b742d4b4c10b96057b433e137712023-11-23T18:20:16ZengMDPI AGNutrients2072-66432022-06-011412239310.3390/nu14122393Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot UlcersRaedeh Basiri0Maria Spicer1Cathy Levenson2Thomas Ledermann3Neda Akhavan4Bahram Arjmandi5Department of Nutrition and Food Studies, George Mason University, Fairfax, VA 22030, USADepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USADepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USADepartment of Family and Child Sciences, Florida State University, Tallahassee, FL 32306, USADepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USADepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USADiabetic foot ulcers (DFUs) are classified as chronic wounds and are one of the most common complications of diabetes. In chronic wounds, management of inflammation is a key step in treatment. Nutrition plays an important role in managing and controlling inflammation. This study evaluated the effects of nutrition supplementation and education on inflammatory biomarkers in patients with DFUs. Eligible patients with foot ulcers were randomly assigned to either a treatment (<i>n</i> = 15) or control group (<i>n</i> = 14). Both groups received standard care for wound treatment from the clinic; however, the treatment group was also provided with nutritional supplementation and education. Plasma concentrations of inflammatory biomarkers, namely C-reactive protein (CRP), interleukin 6 (IL6), interleukin 10 (IL10), and tristetraprolin (TTP), were evaluated at baseline and every four weeks, until complete wound closure had occurred or up to 12 weeks. The mean plasma concentration of IL6 significantly decreased in the treatment group (<i>p</i> = 0.001). The interaction between time and group was not statistically significant for the mean plasma concentrations of CRP, IL10, and TTP during the 12 weeks of the study. The results of this study showed the positive effects of nutritional intervention on controlling inflammation in DFU patients. More clinical trials with a larger population and longer duration of time are needed to confirm our results.https://www.mdpi.com/2072-6643/14/12/2393nutrient supplementationnutrition educationdiabetesdiabetic foot ulcerchronic woundspro-inflammatory cytokines |
| spellingShingle | Raedeh Basiri Maria Spicer Cathy Levenson Thomas Ledermann Neda Akhavan Bahram Arjmandi Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers Nutrients nutrient supplementation nutrition education diabetes diabetic foot ulcer chronic wounds pro-inflammatory cytokines |
| title | Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers |
| title_full | Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers |
| title_fullStr | Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers |
| title_full_unstemmed | Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers |
| title_short | Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers |
| title_sort | improving dietary intake of essential nutrients can ameliorate inflammation in patients with diabetic foot ulcers |
| topic | nutrient supplementation nutrition education diabetes diabetic foot ulcer chronic wounds pro-inflammatory cytokines |
| url | https://www.mdpi.com/2072-6643/14/12/2393 |
| work_keys_str_mv | AT raedehbasiri improvingdietaryintakeofessentialnutrientscanameliorateinflammationinpatientswithdiabeticfootulcers AT mariaspicer improvingdietaryintakeofessentialnutrientscanameliorateinflammationinpatientswithdiabeticfootulcers AT cathylevenson improvingdietaryintakeofessentialnutrientscanameliorateinflammationinpatientswithdiabeticfootulcers AT thomasledermann improvingdietaryintakeofessentialnutrientscanameliorateinflammationinpatientswithdiabeticfootulcers AT nedaakhavan improvingdietaryintakeofessentialnutrientscanameliorateinflammationinpatientswithdiabeticfootulcers AT bahramarjmandi improvingdietaryintakeofessentialnutrientscanameliorateinflammationinpatientswithdiabeticfootulcers |