Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review
ContextTumor-associated cutaneous vascular disorder induced by PPGL was extremely rare, and the cutaneous manifestations could disappear after removal of the tumors. However, the definite pathological diagnosis and the potential mechanism remained unidentified. We presented a severe cutaneous vascul...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1065350/full |
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| author | Yinjie Gao Yinjie Gao Yunying Cui Yunying Cui Zhonghui Hu Yu Wang Yu Wang Tianyi Li Tianyi Li Yuehua Liu Anli Tong Anli Tong |
| author_facet | Yinjie Gao Yinjie Gao Yunying Cui Yunying Cui Zhonghui Hu Yu Wang Yu Wang Tianyi Li Tianyi Li Yuehua Liu Anli Tong Anli Tong |
| author_sort | Yinjie Gao |
| collection | DOAJ |
| description | ContextTumor-associated cutaneous vascular disorder induced by PPGL was extremely rare, and the cutaneous manifestations could disappear after removal of the tumors. However, the definite pathological diagnosis and the potential mechanism remained unidentified. We presented a severe cutaneous vascular lesion manifested as diffuse erythema with ulceration and necrosis over the limbs in a female patient with metastatic paraganglioma. Skin biopsy was performed on her for defining the pathological diagnosis and potential mechanism. The patient was diagnosed as vascular disease according to the obvious angioectasia in dermis on cutaneous pathology, which might be caused by PPGL-induced hypercoagulability. We used the antiplatelet therapy with aspirin to treat the PPGL-associated cutaneous vascular disease for the first time, and the cutaneous lesions were relieved and healed gradually, further supporting the diagnosis of vascular disease.ConclusionFor metastatic PPGL patients like the case we reported, the definite diagnosis by skin biopsy and the early antiplatelet therapy might be effective to the cutaneous lesions caused by the hypercoagulable state of PPGL. |
| first_indexed | 2024-04-11T08:00:05Z |
| format | Article |
| id | doaj.art-3dfaf09ec8b54f31888f8ef546f779ee |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T08:00:05Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3dfaf09ec8b54f31888f8ef546f779ee2022-12-22T04:35:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.10653501065350Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature reviewYinjie Gao0Yinjie Gao1Yunying Cui2Yunying Cui3Zhonghui Hu4Yu Wang5Yu Wang6Tianyi Li7Tianyi Li8Yuehua Liu9Anli Tong10Anli Tong11NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaNHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment of Dermatology, Peking Union Medical College Hospital, Beijing, ChinaNHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaNHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaDepartment of Dermatology, Peking Union Medical College Hospital, Beijing, ChinaNHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaContextTumor-associated cutaneous vascular disorder induced by PPGL was extremely rare, and the cutaneous manifestations could disappear after removal of the tumors. However, the definite pathological diagnosis and the potential mechanism remained unidentified. We presented a severe cutaneous vascular lesion manifested as diffuse erythema with ulceration and necrosis over the limbs in a female patient with metastatic paraganglioma. Skin biopsy was performed on her for defining the pathological diagnosis and potential mechanism. The patient was diagnosed as vascular disease according to the obvious angioectasia in dermis on cutaneous pathology, which might be caused by PPGL-induced hypercoagulability. We used the antiplatelet therapy with aspirin to treat the PPGL-associated cutaneous vascular disease for the first time, and the cutaneous lesions were relieved and healed gradually, further supporting the diagnosis of vascular disease.ConclusionFor metastatic PPGL patients like the case we reported, the definite diagnosis by skin biopsy and the early antiplatelet therapy might be effective to the cutaneous lesions caused by the hypercoagulable state of PPGL.https://www.frontiersin.org/articles/10.3389/fmed.2022.1065350/fullpheochromocytoma/paragangliomadiffuse erythematumor-associated cutaneous vascular disordersantiplatelet therapyhypercoagulability |
| spellingShingle | Yinjie Gao Yinjie Gao Yunying Cui Yunying Cui Zhonghui Hu Yu Wang Yu Wang Tianyi Li Tianyi Li Yuehua Liu Anli Tong Anli Tong Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review Frontiers in Medicine pheochromocytoma/paraganglioma diffuse erythema tumor-associated cutaneous vascular disorders antiplatelet therapy hypercoagulability |
| title | Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review |
| title_full | Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review |
| title_fullStr | Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review |
| title_full_unstemmed | Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review |
| title_short | Case report: Antiplatelet therapy on metastatic paraganglioma-associated cutaneous vascular disease and literature review |
| title_sort | case report antiplatelet therapy on metastatic paraganglioma associated cutaneous vascular disease and literature review |
| topic | pheochromocytoma/paraganglioma diffuse erythema tumor-associated cutaneous vascular disorders antiplatelet therapy hypercoagulability |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1065350/full |
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