Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss

Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss

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Abstract In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and high-throughput analyses, we demonstrate that prolonged...

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Bibliographic Details
Main Authors: Xianyi Meng, Zhen Lin, Shan Cao, Iga Janowska, Koshiro Sonomoto, Darja Andreev, Knab Katharina, Jinming Wen, Karl Xaver Knaup, Michael Sean Wiesener, Gerhard Krönke, Marta Rizzi, Georg Schett, Aline Bozec
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00189-x

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