The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency
Abstract Background and Objective: Glutathione as a master antioxidant plays a key role in eliminating free radicals from your body and in preserving cell membrane integrity esp. blood cells. We aimed to assess the Erythrocyte Glutathione level of favism and non-favism neonates. Material and Methods...
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| Format: | Article |
| Language: | English |
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Golestan University of Medical Sciences
2014-01-01
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| Series: | Medical Laboratory Journal |
| Subjects: | |
| Online Access: | http://mlj.goums.ac.ir/article-1-338-en.html |
| _version_ | 1819078004440039424 |
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| author | H Rafeemehr |
| author_facet | H Rafeemehr |
| author_sort | H Rafeemehr |
| collection | DOAJ |
| description | Abstract
Background and Objective: Glutathione as a master antioxidant plays a key role in eliminating free radicals from your body and in preserving cell membrane integrity esp. blood cells. We aimed to assess the Erythrocyte Glutathione level of favism and non-favism neonates.
Material and Methods: This study was conducted in Ekbatan hospitals of Hamadan (2009) on 15 favism patients and 60 non-favism ones matched by sex and age. Using Beutler method, the reduced Glutathione (GSH) level of red blood cells was measured.
Results: Based on the results, the amount of erythrocyte GSH in favism patients was 14.99±4.62 mg/dl and that of controls was 58.2±10.59 mg/dl.
Conclusion: the results show that the erythrocyte GSH in favism patients is significantly lower than that of non-favism subjects therefore, the former seems more likely to be afflicted by hemolytic crises owing to the use of oxidant stuff.
Keywords: Favism Glutathone Neonates G6PD |
| first_indexed | 2024-12-21T19:06:12Z |
| format | Article |
| id | doaj.art-3dfe158ea0d8485198c7a19540739c09 |
| institution | Directory Open Access Journal |
| issn | 2538-4449 |
| language | English |
| last_indexed | 2024-12-21T19:06:12Z |
| publishDate | 2014-01-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj.art-3dfe158ea0d8485198c7a19540739c092022-12-21T18:53:20ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492014-01-0174912The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD DeficiencyH Rafeemehr0 Assistant Professor of Hematology, Department of Medical Laboratory Sciences, Faculty of Paramedicine, Hamedan University of Medical Sciences, Hamedan, Iran Abstract Background and Objective: Glutathione as a master antioxidant plays a key role in eliminating free radicals from your body and in preserving cell membrane integrity esp. blood cells. We aimed to assess the Erythrocyte Glutathione level of favism and non-favism neonates. Material and Methods: This study was conducted in Ekbatan hospitals of Hamadan (2009) on 15 favism patients and 60 non-favism ones matched by sex and age. Using Beutler method, the reduced Glutathione (GSH) level of red blood cells was measured. Results: Based on the results, the amount of erythrocyte GSH in favism patients was 14.99±4.62 mg/dl and that of controls was 58.2±10.59 mg/dl. Conclusion: the results show that the erythrocyte GSH in favism patients is significantly lower than that of non-favism subjects therefore, the former seems more likely to be afflicted by hemolytic crises owing to the use of oxidant stuff. Keywords: Favism Glutathone Neonates G6PDhttp://mlj.goums.ac.ir/article-1-338-en.htmlfavismglutathoneneonatesg6pd |
| spellingShingle | H Rafeemehr The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency Medical Laboratory Journal favism glutathone neonates g6pd |
| title | The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency |
| title_full | The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency |
| title_fullStr | The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency |
| title_full_unstemmed | The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency |
| title_short | The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency |
| title_sort | assessment of erythrocyte reduced glutathione concentration in the neonates suffered from g6pd deficiency |
| topic | favism glutathone neonates g6pd |
| url | http://mlj.goums.ac.ir/article-1-338-en.html |
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