Doxorubicin‐induced senescence promotes stemness and tumorigenicity in EpCAM−/CD133− nonstem cell population in hepatocellular carcinoma cell line, HuH‐7

Doxorubicin‐induced senescence promotes stemness and tumorigenicity in EpCAM−/CD133− nonstem cell population in hepatocellular carcinoma cell line, HuH‐7

The therapeutic induction of senescence is a potential means to treat cancer, primarily acting through the induction of a persistent growth‐arrested state in tumors. However, recent studies have indicated that therapy‐induced senescence (TIS) in tumor cells allows for the prolonged survival of a sub...

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Bibliographic Details
Main Authors: Mustafa Karabicici, Sena Alptekin, Zeynep Fırtına Karagonlar, Esra Erdal
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Molecular Oncology
Subjects:
cancer stem cell
EpCAM
hepatocellular carcinoma
therapy‐induced senescence
WNT
Online Access:https://doi.org/10.1002/1878-0261.12916

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