Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis?
Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by the dysregulated host response to an infection. Sepsis, especially septic shock and multiple organ dysfunction is a medical emergency associated with high morbidity, high mortality, and prolonged after-effects. Over t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.829210/full |
| _version_ | 1829118075534835712 |
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| author | Yu-lei Gao Ying Yao Xiang Zhang Fang Chen Xiang-long Meng Xin-sen Chen Chao-lan Wang Yan-cun Liu Xin Tian Song-tao Shou Yan-fen Chai |
| author_facet | Yu-lei Gao Ying Yao Xiang Zhang Fang Chen Xiang-long Meng Xin-sen Chen Chao-lan Wang Yan-cun Liu Xin Tian Song-tao Shou Yan-fen Chai |
| author_sort | Yu-lei Gao |
| collection | DOAJ |
| description | Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by the dysregulated host response to an infection. Sepsis, especially septic shock and multiple organ dysfunction is a medical emergency associated with high morbidity, high mortality, and prolonged after-effects. Over the past 20 years, regulatory T cells (Tregs) have been a key topic of focus in all stages of sepsis research. Tregs play a controversial role in sepsis based on their heterogeneous characteristics, complex organ/tissue-specific patterns in the host, the multi-dimensional heterogeneous syndrome of sepsis, the different types of pathogenic microbiology, and even different types of laboratory research models and clinical research methods. In the context of sepsis, Tregs may be considered both angels and demons. We propose that the symptoms and signs of sepsis can be attenuated by regulating Tregs. This review summarizes the controversial roles and Treg checkpoints in sepsis. |
| first_indexed | 2024-12-13T10:12:49Z |
| format | Article |
| id | doaj.art-3dfe83dd4d6f45898ca2032660a24464 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T10:12:49Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3dfe83dd4d6f45898ca2032660a244642022-12-21T23:51:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-02-011310.3389/fimmu.2022.829210829210Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis?Yu-lei Gao0Ying Yao1Xiang Zhang2Fang Chen3Xiang-long Meng4Xin-sen Chen5Chao-lan Wang6Yan-cun Liu7Xin Tian8Song-tao Shou9Yan-fen Chai10Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency Medicine, Rizhao People’s Hospital of Shandong Province, Rizhao, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Medical Research, Beijing Qiansong Technology Development Company, Beijing, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaSepsis is a syndrome characterized by life-threatening organ dysfunction caused by the dysregulated host response to an infection. Sepsis, especially septic shock and multiple organ dysfunction is a medical emergency associated with high morbidity, high mortality, and prolonged after-effects. Over the past 20 years, regulatory T cells (Tregs) have been a key topic of focus in all stages of sepsis research. Tregs play a controversial role in sepsis based on their heterogeneous characteristics, complex organ/tissue-specific patterns in the host, the multi-dimensional heterogeneous syndrome of sepsis, the different types of pathogenic microbiology, and even different types of laboratory research models and clinical research methods. In the context of sepsis, Tregs may be considered both angels and demons. We propose that the symptoms and signs of sepsis can be attenuated by regulating Tregs. This review summarizes the controversial roles and Treg checkpoints in sepsis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.829210/fullsepsisregulatory T cellspathophysiologycheckpointssecondary infections |
| spellingShingle | Yu-lei Gao Ying Yao Xiang Zhang Fang Chen Xiang-long Meng Xin-sen Chen Chao-lan Wang Yan-cun Liu Xin Tian Song-tao Shou Yan-fen Chai Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis? Frontiers in Immunology sepsis regulatory T cells pathophysiology checkpoints secondary infections |
| title | Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis? |
| title_full | Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis? |
| title_fullStr | Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis? |
| title_full_unstemmed | Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis? |
| title_short | Regulatory T Cells: Angels or Demons in the Pathophysiology of Sepsis? |
| title_sort | regulatory t cells angels or demons in the pathophysiology of sepsis |
| topic | sepsis regulatory T cells pathophysiology checkpoints secondary infections |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.829210/full |
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