Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression

Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression

Hepatocytes secrete retinol-binding protein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated RBP4 levels in the blood. However, in a previous study, we observed that chronic...

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Bibliographic Details
Main Authors: Julia S. Steinhoff, Carina Wagner, Ulrike Taschler, Sascha Wulff, Marie F. Kiefer, Konstantin M. Petricek, Sylvia J. Wowro, Moritz Oster, Roberto E. Flores, Na Yang, Chen Li, Yueming Meng, Manuela Sommerfeld, Stefan Weger, Andrea Henze, Jens Raila, Achim Lass, Michael Schupp
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Lipid Research
Subjects:
vitamin A
retinoids
glucose
hepatic retinol mobilization
retinyl ester storage
obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001018

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